Julie Rehmeyer's 'Through the Shadowlands'
Writer Never Give Up talks about Julie Rehmeyer's new book "Through the Shadowlands: A Science Writer's Odyssey into an Illness Science Doesn't Understand" and shares an interview with Julie ...
Discuss the article on the Forums.

Mitochondrial deficits in autism and impaired immune function

Discussion in 'Other Health News and Research' started by natasa778, May 9, 2014.

  1. natasa778

    natasa778 Senior Member

    Messages:
    1,773
    Likes:
    2,456
    http://www.sciencedaily.com/releases/2014/05/140508172310.htm
     
    nandixon, NK17, Valentijn and 5 others like this.
  2. alex3619

    alex3619 Senior Member

    Messages:
    12,480
    Likes:
    35,011
    Logan, Queensland, Australia
    Interesting. :)
     
    Bob and merylg like this.
  3. natasa778

    natasa778 Senior Member

    Messages:
    1,773
    Likes:
    2,456
    I am looking at environ factors that can influence/downregulate NRF2, and can't get further than retroviruses (surprise, surprise). Ideas?

    Minocycline to the rescue?


    Attenuation of oxidative stress, inflammation and apoptosis by minocycline prevents retrovirus-induced neurodegeneration in mice
     
    NK17 likes this.
  4. taniaaust1

    taniaaust1 Senior Member

    Messages:
    11,895
    Likes:
    12,702
    Sth Australia
    Maybe it is this genetic weakness which causes more autism to be seen among the children at least of those who have ME/CFS if my observations on this have been correct (I think autism is a lot higher among our children). Maybe many of us are carrying a gene affecting these immune cells?
     
    Valentijn likes this.
  5. Marco

    Marco Grrrrrrr!

    Messages:
    2,378
    Likes:
    3,174
    Near Cognac, France
    Insulin resistance?

    Role of nuclear factor (erythroid-derived 2)-like 2 in metabolic homeostasis and insulin action: A novel opportunity for diabetes treatment?

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258535/
     
    natasa778 likes this.
  6. lansbergen

    lansbergen Senior Member

    Messages:
    2,505
    Likes:
    2,710
    From, the abstract http://pediatrics.aappublications.org/content/133/5/e1405

     
  7. natasa778

    natasa778 Senior Member

    Messages:
    1,773
    Likes:
    2,456
    Possible, but I very much doubt it is about them or 'us carrying a genetic weaknes' - given the number of genetic studies all coming up empty (ie one would expect it to have been picked up by now). More likely imo that something is actively interfering with its function ...
     
  8. natasa778

    natasa778 Senior Member

    Messages:
    1,773
    Likes:
    2,456
    Looking into things that regulate/influence Nrf2, I have come across this novel drug - has been in use for many decades in Russia, now being repackaged and re-marketed it seems (but only to Central and East Eu countries http://www.bachpharma.com/origins.php ?? )


     
  9. Marco

    Marco Grrrrrrr!

    Messages:
    2,378
    Likes:
    3,174
    Near Cognac, France
    natasa778 likes this.
  10. natasa778

    natasa778 Senior Member

    Messages:
    1,773
    Likes:
    2,456
    Interesting that this Russian drug I just posted about has been looked into for this:

    An inflammation in adipose tissue study. Impact on insulin resistance and glucose tolerance with gavage administration of GVT® (GVT®) in FVB/N mice

    http://www.bachpharma.com/indications_metabolic_syndrome.php


    There was some talk recently about adipose tissue in ME/CFS if I remember correctly?
     
  11. Marco

    Marco Grrrrrrr!

    Messages:
    2,378
    Likes:
    3,174
    Near Cognac, France
    Metabolic disorders, oxidative stress, mito dysfunction and neuroinflammation do all appear to be linked although how closely is debatable :

    http://www.sciencedaily.com/releases/2012/04/120409103942.htm

    Plus in diabetes, minor bouts of hypoglycemia have been shown to cause neurodegeneration resembling that seen in Alzheimers :

    Brain atrophy linked with cognitive decline in diabetes

    http://www.sciencedaily.com/releases/2013/09/130912093807.htm

    Re ME/CFS - were you thinking of the study associating leptin with the level of fatigue?



     
  12. taniaaust1

    taniaaust1 Senior Member

    Messages:
    11,895
    Likes:
    12,702
    Sth Australia
    I think there may be several genes involved in ME/CFS (maybe affecting methylation or maybe affecting immunity or combos of genes making us susceptable) and hence why just looking for one hasnt yet been easily found.

    Faulty genes more easily allow something else to come along and knock something out.
     

See more popular forum discussions.

Share This Page