The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
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Mitochondria in mental illness

Discussion in 'General ME/CFS News' started by Richie, Oct 26, 2013.

  1. lansbergen

    lansbergen Senior Member

    Declared healthy till the point of no return is reached.
    Sidereal, Wayne and Valentijn like this.
  2. caledonia


    Cincinnati, OH, USA
    Mental illness = methylation problems.
    Methylation is required to make neurotransmitters. Therefore, mental illness is actually physical illness.
    Also, as we ME patients know firsthand, methylation problems create problems with the mitos. If mito function is associated with mental illness, you can see how it's all interrelated.

    There are about 30 diseases associated with methylation problems (both physical and mental), including autism, cancer, Alzheimer's, ME/CFS, anxiety, depression, etc. Treatment for all of these would be more or less the same, i.e. methylation treatment. The same core problem expresses as different diseases in different people due to genetic variations and probably environmental ones too.

    However, medically and politically we don't want to be associated with mental illness due to the stigma and poor treatment options currently available.

    When the world at large catches on to methylation, the stigma of mental illness will be erased, and there will be a lot less chronic illness.
    rosie26 and Wayne like this.
  3. anciendaze

    anciendaze Senior Member

    Just to get back to the original topic, here is a link to a coming paper on metabolic features of the cell danger response.

    Many aspects of cellular signalling are very hard to interpret in terms of published data. We know this signalling works in a noisy environment, under an enormous range of conditions. What we do not know is any natural way the levels can be calibrated, as our laboratory tests are, or how they are encoded to get through biochemical noise. If cells are using differential signalling, missing the other parts of the signal can leave us with nonsense. It would be easy if one signal went down every time another went up, as in systems humans design. Unfortunately, natural systems seldom operate this simply. Levels which indicate how much "biochemical noise" to remove are very likely to have been ignored, or at the very least, left unpublished.

    There is an exception to this unsatisfactory state of affairs in the case of energy. Response to a pathological process must allow supply of molecules which provide energy to power that response. This may be the signal which confirms earlier biochemical signals. It may also be the tag that marks unwanted molecules for degradation, as well as the fuel which drives the process.

    This is an area of research to watch.

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