Is there any difference in trying to treat this vs mitochondria in the rest of the body? And is it caused by the same thing? According to my SPECT I have extensive mitochondria damage in my brain and it has never fluctuated, not even once, since this disease started. In fact, most of my PEM episodes have damaged exclusively my brain and not my body at all. Nothing has helped me at all yet but I'm wondering if there are any different procedures that may effect your brain more so than body. I wonder also if the location of the initial infection has anything to do with it. I had encephalitis and my brain has been 80-90% of the problem for me. Will the mitochondria be damaged more at the site of the infection?