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Misfolded Neural Proteins Linked to Autism Disorders

Discussion in 'Other Health News and Research' started by leela, Sep 11, 2010.

  1. leela

    leela Slow But Hopeful

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    Couchland, USA
    This reminds me of Cort's article "Proteins on the Brain."

    Could be totally unrelated, but seems somehow like an avenue of research for both ME/CFIDS and
    Autism, in that misfolded proteins of kind or another are wreaking havoc on the neuronal connections.
    http://www.sciencedaily.com/releases/2010/09/100910142751.htm

    Misfolded Neural Proteins Linked to Autism Disorders

    ScienceDaily (Sep. 10, 2010) An international team of scientists, led by researchers at the University of California, San Diego, has identified misfolding and other molecular anomalies in a key brain protein associated with autism spectrum disorders.

    Palmer Taylor, associate vice chancellor for Health Sciences at UC San Diego and dean of the Skaggs School of Pharmacy and Pharmaceutical Sciences, and colleagues report in the Sept. 10 issue of the Journal of Biological Chemistry that misfolding of a protein called neuroligin-3, due to gene mutations, results in trafficking deficiencies that may lead to abnormal communications between neurons.
    Genetic misfolding of neuroligins is thought to prevent normal formation and function of neuronal synapses. The gene mutation has been documented in patients with autism.
    "It makes sense that there's a connection," said Taylor. "The neuroligins are involved in maintaining neuronal synapses and their malfunction is likely to affect a neurodevelopmental disease."
    Neuroligins are post-synaptic proteins that help glue together neurons at synapses by connecting with pre-synaptic protein partners called neurexins. They are part of a larger family of alpha-beta-hydrolase fold proteins that includes many molecules with diverse catalytic, adhesion and secretory functions.
    Using live neurons in culture, the researchers found that different mutations caused different degrees of misfolding of the protein structure, which translated into trafficking deficiencies of varying severity regardless of alpha-beta-hydrolase protein type, yet resulted in distinctly different congenital disorders in the endocrine or nervous systems.
    Both neuroligins and the autism mutations are relatively new to science. The former were characterized 15 years ago, the latter discovered just seven years ago. Taylor said identifying and describing the misfolded protein link advances understanding of the complex causes of certain autisms, including the influences of genes versus environment, and perhaps offers a new target for potential drug therapies.
    "If the mutation is identified early, it might be possible to rescue affected neurons before abnormal synaptic connections are established" said co-author Davide Comoletti, a research scientist at the Skaggs School of Pharmacy. "But much work remains. We may be able to find a treatment to fix a cell in culture, but to rescue function in vivo may not be feasible with the same strategy."
    Co-authors with Taylor and Comoletti are Antonella De Jaco of the Department of Pharmacology at the Skaggs School of Pharmacy and Pharmaceutical Sciences and the Department of Cell and Developmental Biology at the Daniel Bovet Neurobiology Research Center, Sapienza University of Rome and the Istituto Pasteur-Fondazione Cenci Bolognetti; Michael Z. Lin of the Departments of Pharmacology and Chemistry and Biochemistry at UC San Diego; Noga Dubi, Meghan Miller and Shelley Camp of the Department of Pharmacology at the Skaggs School of Pharmacy and Pharmaceutical Sciences; Mark Ellisman, Department of Neuroscience, UC San Diego; Margaret T. Butko, Departments of Pharmacology and Chemistry and Biochemistry at UC San Diego and Roger Y. Tsien, Departments of Pharmacology and Chemistry and Biochemistry at UC San Diego.
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    Story Source:
    The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by University of California - San Diego. The original article was written by Scott LaFee.
    Journal Reference:
    A. De Jaco, M. Z. Lin, N. Dubi, D. Comoletti, M. T. Miller, S. Camp, M. Ellisman, M. T. Butko, R. Y. Tsien, P. Taylor. Neuroligin Trafficking Deficiencies Arising from Mutations in the α/β-Hydrolase Fold Protein Family. Journal of Biological Chemistry, 2010; 285 (37): 28674 DOI: 10.1074/jbc.M110.139519
     
  2. tymewarp#9

    tymewarp#9

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    Central California
    Leela, thanks for posting this (more to try to wrap my 'bent proteins' around..!) t.
     

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