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Misdiagnosed chronic pelvic pain: pudendal neuralgia responding to a novel use of palmitoylethanolam

Discussion in 'Other Health News and Research' started by nanonug, Oct 30, 2012.

  1. nanonug

    nanonug Senior Member

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    Pain Med. 2010 May;11(5):781-4. Epub 2010 Mar 22.
    Misdiagnosed chronic pelvic pain: pudendal neuralgia responding to a novel use of palmitoylethanolamide.

    CalabrĂ² RS, Gervasi G, Marino S, Mondo PN, Bramanti P.
    Source

    IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy. roccos.calabro@centroneurolesi.it
    Abstract

    BACKGROUND:

    Pudendal neuralgia is a cause of chronic, disabling, and often intractable perineal pain presenting as burning, tearing, sharp shooting, foreign body sensation, and it is often associated with multiple, perplexing functional symptoms.
    CASE REPORT:

    We report a case of a 40-year-old man presenting with chronic pelvic pain due to pudendal nerve entrapment and successfully treated with palmitoylethanolamide (PEA).
    CONCLUSION:

    PEA may induce relief of neuropathic pain through an action upon receptors located on the nociceptive pathway as well as a more direct action on mast cells via an ALIA (autocoid local injury antagonism) mechanism. As recently demonstrated in animal models, the present case suggests that PEA could be a valuable pharmacological alternative to the most common drugs (anti-epileptics and antidepressants) used in the treatment of neuropathic pain.
    Comment in

    PMID: 20345619
     

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