Discussion in 'Latest ME/CFS Research' started by Cheshire, Nov 11, 2016.
Miriam Tucker has been busy since the conference! It's great to see three good articles appear in Medscape in quick succession - hopefully health professionals reading those will be struck by the evidence for biological disease.
Another article to show my primary care doctor as I try to get him to up-to-speed on both the latest research and the seriousness of this illness. Thanks!
Miriam Tucker's article are always excellent.
Haven't some people here been injured by immune modulators? I want to say Ginger Girl (intentionally not tagging her) might have, and it seems others I have read were too. But my brain is pretty worthless at times.
This sounds like very big, helpful news. Do we know if Ron Davis ' team is involved in this at all. Makes it seem like they already have some drugs in mind and it all fits in with the Metabalon findings of Naviuex, Gordon, Davis....etc.
Sorry, haven't been paying attention. Could someone link all three of Tucker's articles? Thanks
Pyruvate dehydrogenase complex (PDC) is a complex of three enzymes that convert pyruvate into acetyl-CoA.
This conversion is inhibited by mercury, arsenic and antimony. These metals also inhibit other conversions farther along in the Kreb's cycle.
Mercury and lead also inhibit methionine synthase, aka screw up the methylation cycle. Mercury also screws up many other enzymes and pathways in the body (CBS/transsulfuration) is another example.
The committment by Fluge and Mella to this illness is much appreciated. Especially that they are also looking at genetics, metabolomics, blood vessels, and other things besides B cell depletion (which may very well turn out to help only a subset).
You can also try a Google Site Search
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