Agents for Change: The 10th Invest in ME International ME Conference, 2015 - Part 1
The 10th Invest in ME International ME Conference (IIMEC10) was held, as usual, in the Lecture Theatre at 1 Birdcage Walk in Westminster on May 29th, 2015.
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Minocyclin

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by glenp, Dec 29, 2010.

  1. glenp

    glenp "and this too shall pass"

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    I couldn't find the minocyclin thread. Has anyone had negative affects from minocyclin? I have been taking minocyclin for 6 months and have had much improvement. I've noticed ringing in my ears which really scares me and wonder if anyone has had any bad affects from it. I have had damage from gentamycin so am very cautious now - I just stopped and will call my doctor tomorrow. I really hate to stop - It has improved my migraines and head pain dramatically. I am wondering if the ringing in the ears could be it affecting the inner ear as gentamycin can?? and that is permanent?? I called the pharmassist who said all symptoms disappear after treatment is stopped!!!! ???

    Thank you
    glen
     
  2. aruschima

    aruschima I know nothing

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    Hi Glenp,

    1.The ringing in the ear sounds like Tinnitus and sounds like a side effect of Minocycline

    Side effects

    Minocycline may cause upset stomach, diarrhea, dizziness, unsteadiness, drowsiness, headache and vomiting. Minocycline increases sensitivity to sunlight. It has also been linked to cases of lupus. Minocycline can reduce the effectiveness of oral contraceptives.[8] Prolonged use of minocycline over an extended period of time can lead to blue-gray skin (permanent blue discoloration of gums) or teeth discoloration. Rare but serious side effects include fever, yellowing of the eyes or skin, stomach pain, sore throat, vision changes, and mental changes, including depersonalization.[9][10]
    Minocycline, but not other tetracyclines, can cause vestibular disturbances with dizziness, ataxia, vertigo and tinnitus. This side effect is much more common in women than in men, occurring in 50% to 70% of women receiving minocycline. As a result of the frequency of this bothersome side effect, minocycline is rarely used in female patients.[11]
    Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, and trouble breathing.[9] Minocycline has also been reported to cause idiopathic intracranial hypertension (pseudotumor cerebri).
    ADVERSE REACTIONS Others: Thyroid cancer has been reported in the post-marketing setting in association with minocycline products. When minocycline therapy is given over prolonged periods, monitoring for signs of thyroid cancer should be considered

    http://en.wikipedia.org/wiki/Minocycline

    2. Minocycline is known for its bad side effect and can also induce, or activate dormant autoimmune diseases.

    I had a long thread on prohealth years ago on
    You can find it here :http://www.prohealth.com/fibromyalgia/blog/boardDetail.cfm?id=1015520&setBoard=FM#1015520

    In my opinion: not a good idea to take ABX for patients with ME/CFS, especially those who have autoimmune (like) issues. But if it helped you, you might be able to change to one which has less side effects than Minocycline, if you intend to take ABX for a longer period.

    Hope that helps.

    Aruschima
     
  3. SOC

    SOC

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    I tried Minocylcine 18-24 months ago for a couple of weeks. It made me very nauseous and I didn't see any other change during that time so I quit. I tried again a couple of months later with the same result, so I gave up on it.

    I didn't have any ringing in my ears, though.
     
  4. FunkOdyssey

    FunkOdyssey Senior Member

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    Minocycline: inhibiting NF-KappaB in the brain, inhibiting microglial activation, inhibits HIV replication, protects brains of mice from an MLV (close relative of XMRV). Seems like it would at least help via NF-KappaB inhibition, and if we were really lucky might directly inhibit XMRV replication as it does in HIV. The list of studies documenting one or another neuroprotective feature of minocycline is ridiculously long now but I will limit this to what seems most relevant to XMRV:

    Has anyone tried Minocycline for XMRV?
     
  5. glenp

    glenp "and this too shall pass"

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    Ty for your replies

    It has really helped me for the 6 months I have been on it ---- helps my head. I hated to stop but am terrified of the buzzing ears - thinking back to when I took gentamycin and got permanent damage - idk if it could cause permanent inner ear damage or not? It really has helped -- migraines, soar head, smells that aren't there, and also soar throat

    glen
     
  6. pine108kell

    pine108kell Senior Member

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    I always a little surprised when I read that people with CFS can tolerate minocycline for long periods. The die off for me is horrenduous and turns me into a basket case in less than a week. It makes me feel better for a few days because of the anti-inflammatory properties then the die off response becomes unbearable. I definitely have more signifigant bacterial infections (seem to have lyme) or a very different immune system.

    I wonder if the benefits you are recieving are from killing organisms or the anti-inflammatory response? If it is the latter, maybe something else will help--I wish I knew what would give the benefits of the powerful anti-inflammatory response relevant to CFS without the die off or long term abx use.
     
  7. dwy904

    dwy904

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    Did your ear ringing go away ?

    I had minocycline for 1 month and 9 days. After I felt the ringing in ear I stopped right away. The ringing decrease a lot during these four weeks. But I can still hear a little bit. Will it go away ? I am scared.
     
  8. AlmostEasy

    AlmostEasy

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    If you receive that sort of die off that sounds clearly like a herx reaction as you're aware of. If the OP received benefit immediately, as I do, then it's almost certainly from it's anti inflammatory properties. I benefit from it almost immediately but taking it twice daily makes me feel incredibly strange and once daily isn't quite enough to eliminate my inflammation. I might play with it more.

    I don't know the OP's story but I would recommend treating the cause of the inflammation in the first place rather than to continually use an antibiotic long term. I don't think that is a good strategy unless you've gone through extreme measures for years on end without finding any type of solution or reason for your dysfunction. With how much these drugs can alter your microbiome it's a bit frightening when you hear of someone using these long term.

    Using potentially just as powerful natural remedies might afford you similar benefits without the potential of tinnitus and turning your skin permanently blue. I would read through the thread I linked and see if you can find any relief with those if you don't know the root cause of your disorder.
     
  9. prioris

    prioris Senior Member

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    The Lederle minocin cure my FMS over 15 years ago. I took it ever day for two years. I had no negative effects except plaque build up on teeth. The generic minocycline didn't work. The best low cost minocycline is Teva and Ranbaxy. The original minocin was time release pellets and the price has skyrocketed where only bill gates can afford it. The way it helps is by helping the immune system. Except for amoxicillin, I say away from all other antibiotics. They can wipe out your intestinal flora. Cipro has been deadly to a lot of people. Everyone responds to antibiotics differently so people can have very negative reaction to the drug. Some people are told that a bad reaction to antibiotics is just the die off. That's debatable. Well, when I had that so called die off with other antibiotics, I just stopped taking it after 2 days.

    I have had ringing in ears for the last 40 years. I have ignored it since I am buried with more important symptoms. I still have good hearing.
     
  10. dwy904

    dwy904

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    I only had minocycline for 1 month and 9 days and the ringing sound decrease a lot during following four weeks but it has not completely gone yet. I am so worried.
     
  11. prioris

    prioris Senior Member

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    Roughly 10 percent of the adult population of the United States has experienced tinnitus lasting at least five minutes in the past year. This amounts to nearly 25 million Americans.

    If it is decreasing then it's getting better. the fact that you are headed in the right direction is a positive sign. You will have to research the serious consequences for certain situations. my ringing gets better then get worse then gets better then gets worse ... i never had time to pay much attention to it. when i try to take b12 or folate the ringing gets worse. use your intuition to tell you what to do.
     
  12. dwy904

    dwy904

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    For the first and second week, it was like motor sound. During the third week the sound reduced so much and the sound was like 'si si si si' and the motor sound was gone. During the fourth week, the sound is still 'si si si si' but it seems like it increase a little bit these day which is the end of the fourth week. I really have no idea how it will end up. T_T
     
  13. AlmostEasy

    AlmostEasy

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    That is interesting, I don't know much about FMS.

    Did you take the Lederle minocin initally? How long did it take to help? Did symptoms come back when you tried the generic minocycline? Are you saying that the Teva and Ranbaxy minocycline helped during these 2 years or in subsequent years have you just researched and found them to be effective compared to generic?

    That is true some of the side effects are similar to a herxheimer reaction. Having a confirmation for Lyme might help in the decision to push through or quit.

    Do you have ME/CFS issues now that you tried to treat with antibiotics that gave you poor reaction?
     

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