Hi all- I was researching autism (which seems to have some relation to CFS, at least in terms of methylation and sensitivity to sound/visual stimuli) and found that rs7794745 is one of the most researched SNPs related to autism. Most people with the relatively common risky version (TT) don't have Autism, but being heterozygous or homozygous for the SNP does make people more susceptible to expressing autistic traits. Even people without autism have differences in brain structure if they have this SNP, with a more developed frontal cortex but less connections to other regions of the brain (for more info check out http://healthland.time.com/2010/11/03/study-some-autistic-brains-really-are-wired-differently/ or you can see the studies by searching for the gene, CNTNAP2) I am curious about people's SNPs and whether they think they had any ADHD/autistic tendencies before they got CFS. https://www.23andme.com/you/explorer/snp/?snp_name=rs7794745 should show you your value if you use 23andme. I am homozygous for the risk polymorphism (TT) and had slight ADHD tendencies before getting sick, but was ok with stimuli and social interactions before getting sick. My current half-baked theory for my CFS onset is that mold toxins/air pollution caused additional damage in my limbic system and/or frontal lobe which tipped me over the edge, and my mast cell problems/ NK cell dysfunction is downstream of brain damage. Theory subject to change as always and specific to my own situation which involved an insidious onset.... Thanks everyone! The ability to do citizen research on PR is fantastic.