I'm aware that the combination of reduced cortisol and increased ACTH is suggestive of primary adrenal insufficiency. In my case, these parameters are only mildly abnormal so they are a bit in a grey area. I'm interested in hearing other people's inputs or experiences in this matter because I find them quite valuable. Do doctors tend to underestimate the importance of these findings? Did anyone have success with low dose cortisone therapy? If so, in what timeframes can improvement be expected? Days, weeks, months, a year? Are further lab tests aimed at elucidating HPA axis function and integrity justified? If so, what lab tests should I get? Mildly decreased cortisol = ~90% of lowest reference value. Mildly increased ACTH = ~110% of highest reference value.