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Mikovits talk in Oslo

Discussion in 'Media, Interviews, Blogs, Talks, Events about XMRV' started by Daffodil, Dec 14, 2010.

  1. Daffodil

    Daffodil Senior Member

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    from ESME:


    Excerpts of the
    XMRV-conference in
    Oslo on 28/12/2010

    Lecture by Dr. Judy Mikovits, Whittemore
    Peterson Institute

    Dr. Mikovits began by acknowledging several other
    famous researchers and telling about her
    collaborations with them, including several
    researchers at the National Cancer Institute, the
    Cleveland Clinic, the SAIC and, of course, the
    Whittemore Peterson Institute.

    Dr. Mikovits proceeded by explaining how the novel
    retrovirus was found in prostate cancer patients in
    2006 and 2007, and named XMRV Xenotropic Murine
    Leukemia virus-Related Virus.

    She showed how the infectious clone was
    constructed and sequenced and found to be a novel
    human gammaretrovirus.

    Dr. Mikovits then showed how ME/CFS patients have
    several inflammatory sequelae including antiviral
    enzyme dysfunction (RNase L), decreased NK cell
    number and function, increase in activated T cells
    and increases in inflammatory cytokines/chemokines.

    She believes that these dysfunctions might be
    explained by an ongoing retroviral infection and
    proposed that these patients could be infected with
    XMRV.

    Dr. Mikovits went through some of the technical
    information on how they were able to detect XMRV
    proteins and positive antibodies leading up to the
    October 9th , 2009 Science article.

    She also gave the audience a little insight into newer
    detection techniques that are currently being
    developed.

    Dr. Mikovits showed possible reasons for the
    disparity in XMRV detection, including patient
    selection in heterogeneous diseases, variation in
    methods, possibility of scattered world-wide
    distribution (as in HTLV1), higher levels of sequence
    diversity, looking for retrovirus in blood, prostate
    cancer not being the in vivo reservoirs, and false
    positives due to PCR contamination with mouse
    cells.

    She showed that infectious XMRV and antibodies
    were found in samples from UK ME/CFS patients and
    in Norwegian patients. The Norwegian study is
    ongoing and Dr. Mikovits is cooperating on it with Dr.
    Johnsgaard of the Lillestrrm Clinic. She then went on
    to explain the finding of 2 strains, XMRV and PMRV,
    and the probability that both can be present at the
    same time in the same patient.

    Dr. Mikovits showed a slide that made it obvious
    that the virus has a simpler make-up than HIV and
    HTLV1.

    Interestingly, the LTR is stimulated by hormones,
    proving why the LNCaP cell line is the best choice. It
    might also be a possible clue to pathogenesis as
    hormones and inflammation might increase the
    replication of XMRV.

    HTLV1, a complex deltaretrovirus is not present in
    Europe or the US, but does exist in many individuals
    in other countries and carries a 10% lifetime risk of
    developing cancer and inflammatory syndromes.
    XMRV is probably more similar to HTLV than to HIV.
    HTLV is asymptomatic in the majority of individuals.

    Dr. Mikovits ended her talk by showing some
    cytokine/chemokine profiles found in adult T cell
    lymphoma/leukemia and comparing them to many of
    the same findings in patients with XMRV.

    ESME in cooperation with Dr. Mette Johnsgaard
    Medical Reporter of the ESME Think Tank

    ````````

    Excerpts of the
    XMRV-conference in
    Oslo on 28/12/2010

    Lecturer of Dr. Mette Johnsgaard,
    Lillestrom Helseklinikk, Center for
    Treatment of Chronic Diseases:

    Dr Mette Sophie Johnsgaard opened her speech by
    introducing Lillestrrm Helseklinikk, Center for
    Treatment of Chronic Diseases, where she is medical
    director.

    They see approximately 600 patients per month,
    most Norwegian patients, but also some Danish and
    Swedish patients visit the clinic, and lately patients
    have been contacting them also from the Continent.
    Today 3 physicians work at Lillestrrm, mainly with
    ME/CFS patients.

    Dr Johnsgaard showed the audience the impressive
    list of her support group. Together with the two
    other physicians at the clinic, she has traveled
    extensively the last year, visiting several well known
    ME/CFS experts in order to learn as much as possible
    on diagnosis and treatment in patients with ME/CFS.

    This has enabled the doctors to find the best
    possible treatment plan for every individual patient.

    She continued talking about the patient group in
    focus, especially what triggers disease and the
    amount of reactivating viruses and chronic infections,
    as this is information that can be important for
    treatment and also give a better understanding of
    the disease.

    She also mentioned gastrointestinal disorders
    including inflammation, bacterial overgrowth,
    parasite, inflammation and food intolerances.

    Both the chronic and reactivating infections and the
    bowel inflammation and persistent parasite
    inflammations are common in other retroviral
    disorders, making the XMRV story plausible.

    Dr Johnsgaard honestly explained how a normal
    Norwegian GP has very little knowledge on
    retroviruses; neither HTLV nor HIV is often seen in a
    GPs office.

    This makes the connection between retrovirus and
    ME/CFS difficult to see, even after the positive
    studies showed possible connection to the disease.

    She told the audience how she was reluctant to send
    samples testing for XMRV virus until more was known
    on the matter, however, as patients constantly kept
    putting pressure on the clinic, they finally decided to
    send samples to VIPdx, a CLIA certified laboratory.
    The positive samples came as a big surprise to both
    doctors and some patients, and the need for
    Norwegian research seemed obvious.

    She continued explaining how many samples where
    positive in cell culture and/or serology, and showed
    connections between Karnofsky score and positive
    samples. The material is of yet not published.

    Dr Johnsgaard showed us a couple of patient
    examples.

    2 co-workers got sick about the same time with a
    hard influenza-like disease. One developed a chronic
    neurological pain disorder but no exhaustion, the
    other a classical ME/CFS. They are both XMRV
    positive.

    A patient develops ME/CFS after an accident, but had
    bouts of chronic sinusitis and tendinitis years before
    the accident. The house proved to have molds and
    she could pin point many symptoms having started
    as she moved into the house.

    After renovating the house, she has experienced a
    great improvement on biotoxin therapy as used by
    Dr Ritchie Shoemaker, with whom Dr Johnsgaard is in
    close contact with. The patient does however also
    have positive XMRV.

    Here is the conclusion to the Dr.
    Johnsgaard's experience at Lillestrrm
    helseklinikk so far:

    - Many different triggers give the same
    disease

    - Chronic infections and reactivated
    viruses are common and need treatment

    - Many patients have gastrointestinal
    disorders that can be treated

    - Many patients have biotoxin disease that
    can be treated

    - Clusters of ME/CFS are seen in families
    and areas

    - Partners do and do not get sick

    - There is an overweight of cancer and
    autoimmune diseases in the family of
    patients with ME/CFS

    - Varying effect on treatment protocols
    makes it important to have individual, tight
    follow up

    - Many patients get better after treatment
    up to a certain point, pointing to the
    possibility of treating secondary effects in
    a retroviral infection.

    What can be treated to day:

    - Chronic / reactivated infections

    - Gut inflammation

    - Biotoxin disease

    - Inflammation

    - Immune pathologies, to a certain
    degree

    It is too soon to try anti retroviral treatment. More
    research is needed.

    Dr Johnsgaard continued her speech talking about
    the ongoing research: "NO-CFS, stage 1, confirmatory
    study for the detection of gamma retrovirus related
    sequences".

    The research is being conducted in cooperation with
    the WPI, USA and the San Raffaele Scientific
    Institute in Milan, Italy.

    She also mentioned several planned research
    projects planned for 2011, including research in
    biotoxin disease in cooperation with Dr. Ritchie
    Shoemaker and bigger international studies for
    human gammaretrovirus.

    Dr Johnsgaard's speech was constantly pointed back
    to the patients, and at this point she talked about
    two patients she has been treating.

    The first was a young girl who was extremely sick
    without any offered treatment nor explanation for her
    ME/CFS symptoms.

    After one year of treatment she is back to normal
    life.

    The other, a young boy has been bedridden for years,
    mysteriously extremely ill. He is so sick that he
    cannot interact with even his parents without it
    being a great strain for him. He has told his mother
    he plays in the garden with his friends inside his
    head. That is all he can manage.

    No treatment has had any effect so far, and Dr
    Johnsgaard pointed out that the extremely ill
    patients are one of the major reasons she feels
    research is so important.

    He is also one of the reasons why it is so
    important to ban blood donations from ME/CFS
    patients. If there is the slightest chance that a
    transmissible agent can lead to such a debilitating
    disease, one should stop any possible route of
    transmission.

    As a summary Dr Johnsgaard showed off
    the following slide:

    ME is a serious disease. It reduces life
    function more than most other diseases
    seen in a GPs office. It is also a great
    burden on society.

    We know through research that ME/CFS
    patients have reactivated viruses and
    chronic bacterial infections

    We know through research that ME/CFS
    patients have immune pathologies

    Concerning retrovirus:

    We know XMRV is a novel human gamma
    retrovirus

    We know HTLV is associated with cancer
    and inflammatory diseases

    We know HIV is associated with severe
    immune deficiencies

    We believe XMRV is related to certain
    types of cancer

    We believe XMRV is related to a chronic
    immune inflammation

    We believe XMRV is only one of several
    gamma retroviruses that will be isolated
    over the next years, opening up for the
    possibility for explaining different degrees
    of severity in patients with ME/CFS

    We need more research, and for research
    we need funding

    We need cooperation between
    researchers

    Relevant research has to benefit patients
    without delay

    We need an updated patient information
    channel

    Lillestrrm helseklinikk will continue to treat what is
    possible, and to follow up research:
    www.lillestromhelseklinikk..no

    ``````
     
  2. Merry

    Merry Senior Member

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    Columbus, Ohio, USA
    Thank you, Daffodil. Quite interesting.
     
  3. slayadragon

    slayadragon Senior Member

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    twitpic.com/photos/SlayaDragon
    >Dr. Mikovits then showed how ME/CFS patients have several inflammatory sequelae including antiviral enzyme dysfunction (RNase L), decreased NK cell number and function, increase in activated T cells and increases in inflammatory cytokines/chemokines.

    Somehow I wasn't aware that the Rnase-L, NKC and T cell abnormalities stem from the inflammation.

    Might anyone be able and willing to elaborate on that a bit?

    Thanks for your help.

    Best, Lisa
     
  4. August59

    August59 Daughters High School Graduation

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    Upstate SC, USA
    Want to keep this thread hot. Anyone??????
     
  5. Deatheye

    Deatheye Senior Member

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    Huh? What am I missing? 28th december?^^
    The text itself is in the past so that seems wierd to me.
     
  6. kat0465

    kat0465 Senior Member

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    Texas
    the Date kinda threw me too, really interesting! thanks daffodil. I'm always amazed how so many peeps on here can find such interesting, in depth, articles.
    if i only had a brain!lol
     
  7. August59

    August59 Daughters High School Graduation

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    Upstate SC, USA
    I'm still confused on the date, but I was going with the flow!!!
     

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