I've been having weird headaches for a couple years and finally saw a neurologist the other day. He says they are most likely migraines (vascular). He gave me a sample of a drug called Treximet (sumatriptan & naproxen sodium - 85/500mg). He told me I should try to take it when I feel a headache coming on. Since my head was feeling a little "off" last night and I had been crying a little bit (I do a lot and crying is a trigger), I decided to take a pill before I went to sleep. I didn't like the way it made me feel...nausea, tightness in my chest, groggy/dizzy, and more emotional. So I went to sleep as usual and also took my normal sleep meds, Ambien CR and Clonazepam 1mg. When I woke up today my head actually felt more "clear" and I was slightly more alert and felt more rested than I have in a LONG time. I certainly wasn't ready to go do anything major, but the effect was noticeable. I would describe it as having more mental energy than physical. Now, it is not feasible for me to take this medicine every night before bed but I'm wondering what action it had on my brain that gave me this boost the next day. I understand that migraines are caused by inflammation in the blood vessels of the brain and I read that the ingredient in that medication (sumatriptan) basically reduces vascular inflammation. So could "brain inflammation" be causing some of the fatigue and brain fog symptoms??