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midodrine not available

Messages
426
Location
southeast asia
Hello.
Does midodrine only available in US? There isnt in my country and i try to search on Australia database drug list it seems there isnt too.
In US if you wanna buy it on pharmacy (not the one on hospital)do you need prescription to get it?
I have tachycardia and palpitation and low bp :(
Also i cant take anything that raise cortisol.

Is there other drug which raise bp but doesnt effect beta2 receptor? (Cause it will cause tachycardia)
 
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Messages
426
Location
southeast asia
I heard there is a natural equivalent while u find it, Butcher's Broom maybe????? something like that.
https://gpjennablog.wordpress.com/exercise-and-nutrition/


other names for midodrine: Amatine®;Apo-Midodrine®
I check the web and for bp it recommended celtic salt n licorice root
Licorice root caused palpitation and increase cortisol.
I dont know about celtic salt but too much salt also increase cortisol.
Before i took too much salt and get attack every morning.

Yes i search the drug list database ingredients for midodrine and there isnt any. :(
Other drug for hypotension will cause tachycardia cause it increase beta receptor.
 

Sushi

Moderation Resource Albuquerque
Messages
19,935
Location
Albuquerque
In US do you need prescription to get it?
I have tachycardia and palpitation and low bp :(
Also i cant take anything that raise cortisol.
Yes, you need a prescription and it is quite an expensive drug. It is not a miracle drug--it helps some, doesn't help others and some can't tolerate it. I am one who could not tolerate it.

Have you tried herbals like Yohimbe?

Best wishes,
Sushi
 
Messages
426
Location
southeast asia
Yes, you need a prescription and it is quite an expensive drug. It is not a miracle drug--it helps some, doesn't help others and some can't tolerate it. I am one who could not tolerate it.

Have you tried herbals like Yohimbe?

Best wishes,
Sushi
Theres no way without prescription?
Well thats bad :(

I dont know about Yohimbe. I read on wiki heres whats it says.
http://en.m.wikipedia.org/wiki/Pausinystalia_johimbe

Pausinystalia johimbe a psychoactive plant that contains the MAOI alkaloid yohimbine. It is widely distributed over the counter as anherbalaphrodisiac.
Yohimbine has been reputed to be helpful for men with erectile dysfunction (ED). This herbal medication can cause tachycardia[citation needed] andhypertension[citation needed] if improperly dosed and should generally be used only under the supervision of a practitioner knowledgeable in herbal medicine. In addition to yohimbine, Yohimbe also contains 55 other alkaloids. Yohimbine accounts for 1–20 percent of its total alkaloid content. Among the others iscorynanthine, an alpha-1 adrenergic receptorblocker.[4] Hence, the use of yohimbe extract in sufficient dosages may provide concomitant alpha-1 and alpha-2adrenoceptors blockade and thus may better enhance erections than yohimbine alone.
 

SOC

Senior Member
Messages
7,849
But isnt calcium channel blocker is for hypertension? and for tachycardia it isnt as effective as beta blocker right?
If you look up beta-blockers, they are said to be for hypertension as well. My doctor was concerned that the CCB might raise my BP too much, so I had to monitor my BP frequently in the beginning. So I don't think the calcium-channel blockers and the beta-blockers are much different in that particular respect, but you should definitely check with your doctor.

There are both short-acting and long-acting calcium-channel blockers, so you might find one that acts faster, if that is important to you.

Is there a reason you don't want to take a tachy med continuously? Perhaps keeping your HR stable with a med, rather than trying to cope in a hurry when you have a crisis situation would be better...?
 
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Sushi

Moderation Resource Albuquerque
Messages
19,935
Location
Albuquerque
I dont know about Yohimbe.
Look at this thread.

For me, Midodrine was one of the worst and scariest drugs I ever tried. I held onto the phone for 6 hours debating on whether to call the paramedics, then it began to wear off. It is not predictable. I had done fine on it for 2 weeks and then suddenly I was dizzy, felt like I was losing consciousness, and a lot of other very distressing symptoms. Others have had similar experiences and others find it very helpful. I guess I am trying to say that it is a drug that is purely for symptoms and the response is unpredictable.

Also, have you tried high doses of Taurine for tachy? Studies show it is very effective for arrhythmias and tachy is sort of in that category. It (fingers crossed) has stopped my episodes of atrial fibrillation. Here is a study: http://www.ncbi.nlm.nih.gov/pubmed/16797868

Sushi
 

taniaaust1

Senior Member
Messages
13,054
Location
Sth Australia
have tachycardia and palpitation and low bp :(

Have you tried florinef. Im wondering if you have POTS or even if your issues are just caused by low blood volume, florinef may help. Florinef is far more common then Midodrine to be being used in us (Sushi's story isn't the only one I've heard of a horror Midodrine story... I don't think too it was rating that highly on a list of prescription drugs that ME/CFS patients use that's not to say it is harmful for all).
 
Messages
426
Location
southeast asia
@SOC yes i know bb is for hypertention thats why its a dilemma.
I dont understand about raised bp from ccb cause ccb for hypertention as well right?

Its not that i dont wanna take bb i do take it but my bp is low and its a problem i try to tackle. Maybe i should have explain better.
 
Messages
426
Location
southeast asia
Look at this thread.

For me, Midodrine was one of the worst and scariest drugs I ever tried. I held onto the phone for 6 hours debating on whether to call the paramedics, then it began to wear off. It is not predictable. I had done fine on it for 2 weeks and then suddenly I was dizzy, felt like I was losing consciousness, and a lot of other very distressing symptoms. Others have had similar experiences and others find it very helpful. I guess I am trying to say that it is a drug that is purely for symptoms and the response is unpredictable.

Also, have you tried high doses of Taurine for tachy? Studies show it is very effective for arrhythmias and tachy is sort of in that category. It (fingers crossed) has stopped my episodes of atrial fibrillation. Here is a study: http://www.ncbi.nlm.nih.gov/pubmed/16797868

Sushi
Well i thought that could be a hope for the better :(

Yes ive heard about taurine and thinking to give it a try.
 
Messages
426
Location
southeast asia
Have you tried florinef. Im wondering if you have POTS or even if your issues are just caused by low blood volume, florinef may help. Florinef is far more common then Midodrine to be being used in us (Sushi's story isn't the only one I've heard of a horror Midodrine story... I don't think too it was rating that highly on a list of prescription drugs that ME/CFS patients use that's not to say it is harmful for all).

Yes i heard about florinef but i thought before midodrine is better cause florinef is a steroid and will effect cortisol and palpitation?

I didnt know midodrine was that bad cause i heard its helpful. But i guess for long term it could be different?

Sorry to all if i sound so problematic :(
 

oceiv

Senior Member
Messages
259
I don't know if this is the same drug, but it has midodrine HCL. It's available in a lot of countries:

http://www.drugs.com/international/gutron.html

You may also do a search for the brand names:

Amatine, ProAmatine

Also, Eon and Global are the drug companies who make the generic midodrine.

It looks like you may be able to purchase this drug from a Canadian pharmacy. Others would know more about this strategy. Not sure if it's a possibility from your country.

You do not sound problematic at all. I had transient (temporary) side effects from midodrine, but they were tolerable and went away. The temporary side effects are weird and your doctor should warn you. But ME/CFS is so variable from person to person. A drug may work well for one patient and not well at all for others.
 

SOC

Senior Member
Messages
7,849
Yes i heard about florinef but i thought before midodrine is better cause florinef is a steroid and will effect cortisol and palpitation?

I didnt know midodrine was that bad cause i heard its helpful. But i guess for long term it could be different?

Sorry to all if i sound so problematic :(
It sounds like you are trying to figure out all the complicated interactions of HR and BP meds by yourself. It might be better if you found a doctor -- maybe a cardiologist or an autonomic specialist -- who understands the subtleties of these medications better than a layperson does.

There are quite a few meds, often used in combination, for OI. Different combinations work better than others depending on the details of your condition. All the medications (and the supplements) have some disadvantages. Messing with your HR and BP can be serious business, not to be undertaken lightly or with insufficient understanding. Figuring out the combination of BP and HR meds most useful for your particular case is the job of a good doctor.
 
Messages
426
Location
southeast asia
It sounds like you are trying to figure out all the complicated interactions of HR and BP meds by yourself. It might be better if you found a doctor -- maybe a cardiologist or an autonomic specialist -- who understands the subtleties of these medications better than a layperson does.

There are quite a few meds, often used in combination, for OI. Different combinations work better than others depending on the details of your condition. All the medications (and the supplements) have some disadvantages. Messing with your HR and BP can be serious business, not to be undertaken lightly or with insufficient understanding. Figuring out the combination of BP and HR meds most useful for your particular case is the job of a good doctor.
Tachycardia+hypotension or POTS isnt common here. POTS still unknown here and i cant even find a neurologist who acknowledge it.

I will try to talk again with my cardiologist. Last time i was asking about ivabradine but the drug seem new and he doesnt seem to like it.
Also i have to try it out first and see how it goes.