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Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection

Discussion in 'Other Health News and Research' started by Waverunner, Jul 15, 2013.

  1. Waverunner

    Waverunner Senior Member

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    Magnesium seems to have very nice antiviral properties in specific patients.

    Science 12 July 2013:
    Vol. 341 no. 6142 pp. 186-191
    DOI: 10.1126/science.1240094

    http://www.sciencemag.org/content/3...um=&utm_campaign=science&utm_source=shortener

    The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free magnesium (Mg2+) concentrations. Individuals with genetic deficiencies in MAGT1 have high levels of Epstein-Barr virus (EBV) and a predisposition to lymphoma. We show that decreased intracellular free Mg2+ causes defective expression of the natural killer activating receptor NKG2D in natural killer (NK) and CD8+ T cells and impairs cytolytic responses against EBV. Notably, magnesium supplementation in MAGT1-deficient patients restores intracellular free Mg2+ and NKG2D while concurrently reducing EBV-infected cells in vivo, demonstrating a link between NKG2D cytolytic activity and EBV antiviral immunity in humans. Moreover, these findings reveal a specific molecular function of free basal intracellular Mg2+ in eukaryotic cells.
  2. SOC

    SOC Moderator and Senior Member

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    Well that might explain my family's high incidence of Hodgkin's lymphoma and ME/CFS. We've long suspected some common genetic abnormality in our ability to handle Epstein-Barr (and other herpesviruses).
  3. Waverunner

    Waverunner Senior Member

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    Yeah, could have to do with EBV. It's a pitty, that doctors don't look more into this and start to prevent cancer, instead of managing cancer after it occured.

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