1. Patients launch a $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
The Chronic Fatigue Initiative and Interview with Mady Hornig
In a follow-up article to the recent IACFS/ME conference presentation in San Francisco, and after speaking at length with Dr. Mady Hornig, 'searcher' delves deeper into the impressive work being completed by the Chronic Fatigue Initiative, and focuses in on those cytokine results ...
Discuss the article on the Forums.

Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection

Discussion in 'Other Health News and Research' started by Waverunner, Jul 15, 2013.

  1. Waverunner

    Waverunner Senior Member

    Messages:
    929
    Likes:
    694
    Magnesium seems to have very nice antiviral properties in specific patients.

    Science 12 July 2013:
    Vol. 341 no. 6142 pp. 186-191
    DOI: 10.1126/science.1240094

    http://www.sciencemag.org/content/3...um=&utm_campaign=science&utm_source=shortener

    The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free magnesium (Mg2+) concentrations. Individuals with genetic deficiencies in MAGT1 have high levels of Epstein-Barr virus (EBV) and a predisposition to lymphoma. We show that decreased intracellular free Mg2+ causes defective expression of the natural killer activating receptor NKG2D in natural killer (NK) and CD8+ T cells and impairs cytolytic responses against EBV. Notably, magnesium supplementation in MAGT1-deficient patients restores intracellular free Mg2+ and NKG2D while concurrently reducing EBV-infected cells in vivo, demonstrating a link between NKG2D cytolytic activity and EBV antiviral immunity in humans. Moreover, these findings reveal a specific molecular function of free basal intracellular Mg2+ in eukaryotic cells.
  2. SOC

    SOC Back to work (easy, part-time work)

    Messages:
    4,435
    Likes:
    4,349
    USA
    Well that might explain my family's high incidence of Hodgkin's lymphoma and ME/CFS. We've long suspected some common genetic abnormality in our ability to handle Epstein-Barr (and other herpesviruses).
  3. Waverunner

    Waverunner Senior Member

    Messages:
    929
    Likes:
    694

    Yeah, could have to do with EBV. It's a pitty, that doctors don't look more into this and start to prevent cancer, instead of managing cancer after it occured.

See more popular forum discussions.

Share This Page