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Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D

Discussion in 'Latest ME/CFS Research' started by heapsreal, Mar 4, 2015.

  1. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    I think this is the study Judy Mikovits is referring to where magnesium threonate increases nk function??
    Eitherway its interesting.


    Abstract
    The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free Mg2+ levels. Individuals with genetic deficiencies in MAGT1 have high levels of Epstein-Barr virus (EBV) and a predisposition to lymphoma. We show that decreased intracellular free Mg2+ causes defective expression of the natural killer activating receptor NKG2D in natural killer (NK) and CD8+ T cells and impairs cytolytic responses against EBV. Remarkably, magnesium supplementation in MAGT1-deficient patients restores intracellular free Mg2+ and NKG2D while concurrently reducing EBV-infected cells in vivo, demonstrating a link between NKG2D cytolytic activity and EBV antiviral immunity in humans. Moreover, these findings reveal a specific molecular function of free basal intracellular Mg2+ in eukaryotic cells.

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894782/
     
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  2. Jammy88

    Jammy88 Senior Member

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    heapsreal likes this.
  3. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    I wonder if the testing for the genetic defect for Mg metabolism is available to patients oe only if in research study.

    It would be good to have tests to help us choose the supplements we need.
     
  4. minkeygirl

    minkeygirl But I Look So Good.

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    I tried magnesium threonate and I felt like i was on speed. I've heard others have had problems with it.
     
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  5. ukxmrv

    ukxmrv Senior Member

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    I had a look and can't see it reported in 23and me. Could be wrong though.
     
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  6. nandixon

    nandixon Senior Member

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  7. JPV

    JPV ɹǝqɯǝɯ ɹoıuǝs

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    It boggles my mind that people still pay attention to this woman.

    Here's what Jonathan Edwards had to say about a video that she recently posted online...

     
  8. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Who cares really.
    opinions are for individuals to make.
     
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  9. Valentijn

    Valentijn The Diabolic Logic

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    Three SNPs are tested. 31 ME patients and 31 controls I have data for all have the same version of two of the SNPs, and the pretty much same amount of each genotype for the third SNP in each group.

    So no indication of anything interesting there, though there's a ton of SNPs on the gene which 23andMe isn't testing.
     
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