Since around 11/1, I've been having random bouts of depression and anxiety - something I haven't experienced in a long time to this degree. I'm trying to narrow it down, and I feel that my changes to methylfolate may be related. Here's what I've changed over the past 1.5 months or so: Lowered mFolate from 6mg (3 doses of 2mg) to 2mg in the morning, because I seemed to have more energy after a few days at the lower dose Lowered molybdenum from 1mg to .25mg to avoid copper depletion Dropped TMG - it was making me irritable Reintroduced mFolate a few times in single doses of 6mg-10mg to see if there was any impact - any differences could've been placebo So it's either the change of seasons (winter ruins me, but usually not until Feb/March) & life in general (which has been pretty great lately), or something above. My questions now: What do you think the likely suspect is? If I reintroduce 6mg of mFolate, do I need to spread it through the day? If I take it all at once, will it "wear off?" I tried taking 6mg Any other guidance? I'm a little hesitant to reintroduce 6mg of mFolate spread throughout the day because I've enjoyed the extra energy from taking less. I'm also hesitant to go back to TMG because of the (slight) irritability. Plus, my tests of adding more mFolate here and there have been wildly inconsistent, sometimes turning things right around, with an extra dose, yet sometimes my best days have been with just 1mg of mFolate. Thanks everyone.