The power and pitfalls of omics part 2: epigenomics, transcriptomics and ME/CFS
Simon McGrath concludes his blog about the remarkable Prof George Davey Smith's smart ideas for understanding diseases, which may soon be applied to ME/CFS.
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Methylfolate timing + depression

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by bigmillz, Dec 1, 2016.

  1. bigmillz

    bigmillz Senior Member

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    Since around 11/1, I've been having random bouts of depression and anxiety - something I haven't experienced in a long time to this degree. I'm trying to narrow it down, and I feel that my changes to methylfolate may be related. Here's what I've changed over the past 1.5 months or so:
    1. Lowered mFolate from 6mg (3 doses of 2mg) to 2mg in the morning, because I seemed to have more energy after a few days at the lower dose
    2. Lowered molybdenum from 1mg to .25mg to avoid copper depletion
    3. Dropped TMG - it was making me irritable
    4. Reintroduced mFolate a few times in single doses of 6mg-10mg to see if there was any impact - any differences could've been placebo
    So it's either the change of seasons (winter ruins me, but usually not until Feb/March) & life in general (which has been pretty great lately), or something above.

    My questions now:
    1. What do you think the likely suspect is?
    2. If I reintroduce 6mg of mFolate, do I need to spread it through the day? If I take it all at once, will it "wear off?" I tried taking 6mg
    3. Any other guidance?
    I'm a little hesitant to reintroduce 6mg of mFolate spread throughout the day because I've enjoyed the extra energy from taking less. I'm also hesitant to go back to TMG because of the (slight) irritability. Plus, my tests of adding more mFolate here and there have been wildly inconsistent, sometimes turning things right around, with an extra dose, yet sometimes my best days have been with just 1mg of mFolate.

    Thanks everyone.
     
  2. Eastman

    Eastman Senior Member

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    I know someone who also experiences random bouts of depression and anxiety. Her methylfolate dosage has been constant at 15 mg, so I doubt it is related to it.

    Maybe it's the season, like you say. Have you been getting less sun than usual at this time of the year?
     
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  3. bigmillz

    bigmillz Senior Member

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    I just wonder sometimes with Deplin being prescribed for this sort of thing.

    Definitely a bit less sun, unfortunately. And regardless of sun, the winter months always get to me. But it's 50 degrees and sunny out o_O
     

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