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Methylfolate Side Effects ?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by daniariete2000, Nov 26, 2012.

  1. daniariete2000

    daniariete2000 Senior Member

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  2. geesiddiqui

    geesiddiqui MTHFREase

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    Yes I've slowly built up levels of folate over time. If I make a big jump I get the headaches and acne. You can take niacin and potassium to address immediately and bring down your dosage.
     
  3. Little Bluestem

    Little Bluestem All Good Things Must Come to an End

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    Is this a good idea? I have read not to split time-release tablets because you lose the time-release function.
     
  4. geesiddiqui

    geesiddiqui MTHFREase

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    I suspect that is to make sure you are not flushing. You can get flush-free niacin, which usually comes in high doses and split that..
     
  5. alex3619

    alex3619 Senior Member

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    The side effects all look like eicosanoid side effects. I am currently experimenting with resverotrol and it seems to counter-act the methylation side effects without inhibiting methylation. However I do have two issues from doing this. The first is more muscle pain, and the second is reduced quantity of sleep. I am still experimenting though.
     
  6. fozzaw

    fozzaw

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    There's a bunch of reports of resveratrol slowing the healing of soft tissue injuries.
     
  7. alex3619

    alex3619 Senior Member

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    Resverotrol impedes eicosanoid synthesis. I can appreciate that this might distort healing. However given that methylation and antioxidants promote the same pathway in opposition to resverotrol (series 2 and 3 eicosanoids), resverotrol needed to suppressive excessive eicosanoid synthesis in my view. As for promoting healing, I have other strategies I am investigating based on immunological principles but I am many months from discussing those.

    So there is a balancing act. Too much eicosanoid synthesis and watch the symptoms multiply. Too little eicosanoids and healing can be impaired. This would be particularly true for gut healing which may mean that resverotrol should not be used without a companion protocol such as methylation or antioxidants.
     
  8. fozzaw

    fozzaw

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    Also with reduced quantity of sleep, there might be reduced quality also (restorative stages) and less growth hormone release.
     
  9. endomeister

    endomeister

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    What specific supplement and dosages are you using?
     
  10. alex3619

    alex3619 Senior Member

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    I am using a capsule that contains 305 mg T98 grape seed derived resveratrol. I am not sure it has a brand name, doh. It also has 195 mg grape seed extract. I am currently taking four of them, but this is probably too much, whereas taking one is not enough.

    As for reduced quality of sleep, I never sleep well anyway, no matter what. LDN has marginally improved that. I think resveratrol/antioxidant/methylation does too. Its not a simple response and I am still trying to figure it out.

    I have just posted a blog on this here:

    http://forums.phoenixrising.me/index.php?entries/is-the-fatigue-in-me-an-eicosanoid-phenomena.1320/
     

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