So having CFS/ME i decided to try Fredd's methylation protocol. (Methylfolate, methylb12, adenosylb12 + cofactors) The B12 gave amazing results sublingually compared to oral that i always used to take it. (Had top end of reference range with 1000mcg oral daily 1 year ago, went down to mid range. Now 900+) But i assume its the folate that caused me problems: First it caused major anxiety and nausea, tremors and sweating. Which went away. A day or two later i start developing rashes, breathing problems and histamine issues from histamine rich foods, heart palps, rapid heart and POTS (ive never had that) 3-4 weeks later, ive discontinued using any folate/b12 over the RDA and only every second day to prevent symptoms. But i still have all the symptoms. I started taking allegra, cromolyn, quercetin, gynostemma and immune modulator by life extension. Still react weirdly to foods with breathing problems and rapid heart. Palpitations are gone with taurine and potassium. Rashes are gone But i still have asthma symptoms nearly all day even on allegra and cromolyn + congested nose 24/7. If anything methylation should reduce histamine? Im lost, doctor is clueless as well. Never had this problem with folic or folinic acid or methylb12 without methylfolate. I have no issue with SAM-e or TMG either.. The rashes were on the legs if that makes a difference. Huge ones with hives under them. I didnt have histamine issues prior to methylfolate (except for seasonal allergies but nothing for the rest of the year) I havent taken any for 2 weeks (i take folinic now to meet RDA or just eat enough leafy greens) but the symptoms are still here. Rapid heartbeat and extreme breathing problems. Im 20. I also dont tolerate exercise now and get out of breath from barely walking. (3 months ago i was working out mildly and cycling semi often with no issues) Now i get huge pulse (100+ and out of breath from walking down the stairs) Ive never had problems with spinach, avocado etc now i cant eat them at all.. Milk makes me nearly ready to go to the ER because i cant breathe at all and feel extremely weird.