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Methylfolate + folinic = more beneficial?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by bigmillz, May 30, 2017.

  1. bigmillz

    bigmillz Senior Member

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    Been experimenting with folinic acid lately, and it's mostly been pretty great. I have an MAOA mutation, so it's hard for me to take too much of either form of folate.

    Today, I took 1600mcg of folinic, which proved to be a bit too much, but about 6 hours later I felt it starting to wear off. So much that I became quite tired. I happened to have some 1mg methylfolate tabs on me, so I took one to get me by.

    A few hours later and I'm feeling GREAT.

    The only other thing I can add to this is that I've noticed taking 800mcg of folinic twice, 6 hours apart, is much more effective for me than 1600mcg all at once.

    Any explanation for this?
     
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  2. PeterPositive

    PeterPositive Senior Member

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    Well,
    both folinic acid and methyfolate are active in the brain, helping the production of dopamine and serotonin so... I guess that's part of the "feeling great" :) And of course it's temporary so it wears off after a while.

    Similarly I take two doses of methylfolate a day and some extra folinic from a B complex.

    cheers
     
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  3. bigmillz

    bigmillz Senior Member

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    Thanks Peter, always good input :) It's definitely temporary sadly.

    I'm going to go back on just folinic and swap a single dose for methylfolate at some point and see what happens.

    Sadly taking a few days off again as the extra dose seemed to push it over the top again - feeling quite edgy this morning. Damn "warrior gene" :D
     
  4. PeterPositive

    PeterPositive Senior Member

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    I know the feeling. :rolleyes: Folate can cause lots of anxiety/nervousness especially for those sensitive to it, and I am one of them.

    I find folinic and methylfolate different too. While I can take up to 3-4mg of the latter with no ill effects but I get jittery with just 800mcg of folinic. Go figure!
     
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  5. arewenearlythereyet

    arewenearlythereyet Senior Member

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    I split my 1200 mcg of Methylfolate into 3 doses 3 hrs apart. This seems to work. Two of those doses I take as part of a b complex which is better than the b,s separately. I think Fredd called this folate's "half life" he said that this was 3-4 hrs I seem to recall.
     
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  6. Gondwanaland

    Gondwanaland Senior Member

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    Could this be low B1?
     
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  7. PeterPositive

    PeterPositive Senior Member

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    In my case, no.
    It's just too much methylfolate :) I guess there's a "safe" dose for everyone after which one starts having side effects.

    I have tried pushing all of the other vitamins in the B complex to see what differences they could make and there's not much of a difference from a certain dosage.. plus, personally, I don't do well with high doses of B1. They kick my stomach and increase brain fog.
     
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  8. Gondwanaland

    Gondwanaland Senior Member

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    Yeah, same here, although I suspect dry Beriberi. Will try to get a diagnosis.

    BTW excess methyl donors can induce a B2 deficiency too, but I don't do very well on B2 either - it dosen't mean I don't need it though.
     
  9. bigmillz

    bigmillz Senior Member

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    Folinic definitely seems more potent, that's for sure
     
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  10. bigmillz

    bigmillz Senior Member

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    @PeterPositive I handle it better when I'm taking B2 as well, but haven't been on that lately as it was giving me some other issues, specifically exacerbating bruxism.
     
  11. Gondwanaland

    Gondwanaland Senior Member

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    Hmmm increasing the need for magnesium and/or potassium and/or manganese for GABA?
     
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  12. bigmillz

    bigmillz Senior Member

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    I've tried both of these without any beneficial results. At first I thought potassium was helping, but upon taking more, the benefits stopped, leaving me grinding away.

    Manganese I'd still have to try.
     
  13. Gondwanaland

    Gondwanaland Senior Member

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    I always try to eat high manganese foods at dinner to ensure proper GABA and melatonin production (doesn't always work though depending on inflammation levels). Quinoa, chick peas, fennel. Unfortunately I can't tolerate sweet potatoes. Sometimes high tryptophan spices help, sometimes they hinder (parsley, Dijon mustard).
     

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