Been experimenting with folinic acid lately, and it's mostly been pretty great. I have an MAOA mutation, so it's hard for me to take too much of either form of folate. Today, I took 1600mcg of folinic, which proved to be a bit too much, but about 6 hours later I felt it starting to wear off. So much that I became quite tired. I happened to have some 1mg methylfolate tabs on me, so I took one to get me by. A few hours later and I'm feeling GREAT. The only other thing I can add to this is that I've noticed taking 800mcg of folinic twice, 6 hours apart, is much more effective for me than 1600mcg all at once. Any explanation for this?