I've been getting methylfolate to work finally...I won't go into much detail yet because it's still in progress and it deserves a full post of its own. But, I've got this brain fog/clumsiness creeping up as I increase the dose. Mostly noticeable once I moved above 800mcg. I'm currently at 1600mcg. I've read online that some people benefited from zinc (http://forums.phoenixrising.me/index.php?threads/zinc-switched-the-lights-back-on.35230/) and niacin (http://mthfr.net/methylfolate-taking-too-much-a-problem/2012/01/08/ - search for "silver bullet") in similar situations. Any other co-factors I might be running myself out of that are worth trying before I dial the methylfolate back down a bit? I feel DAMN good aside from that, so I don't really want to stop yet.