I've started taking 1 mg of methylfolate by Life extension and in some areas I feel better while in others I feel worse. Benefits: Increased focus Increased energy Slightly increased motivation Decreased sleep time from 12 hours to 8-10 Cons: Brain fog Lack of coordination, I keep bumping into things. I was taking clothes out of my dresser and hit the edge with my hand. This has never happened to me before. Memory loss Feeling dumb, not being able to learn things Heart palpitations Symptoms that have not changed: Severe anhedonia Muscle weakness Lack of appetite For B12 I get 150 mcg from my multivitamin in the form of methylcobalamin. My last blood test my B12 levels were at 647 pmol/L. I take my multivitamin every other day as I've noticed that it causes fatigue if I take it everyday. However, this was long before I discovered methylfolate. Could the fatigue from my multivitamin have been due to a methylfolate deficiency? My main goal with methylfolate is to increase BH4, but I've read that methylcobalamin actually decreases BH4 and instead increases methylation. I have no idea what methylation is, but I do know that BH4 is involved in the synthesis of neurotransmitters which is what I'm after. What should I do to decrease the side effects?