New era for ME/CFS research as top cytokine study attracts media headlines
The immune systems of patients who have recently developed ME/CFS look markedly different from those who have been ill for much longer, according to a major new study from Drs. Ian Lipkin and Mady Hornig at Columbia University. This shift in immune function hadn’t been seen before.
Discuss the article on the Forums.

methylfolate and methylcobalamin at same time ?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by daniariete2000, Jun 25, 2014.

  1. daniariete2000

    daniariete2000 Senior Member

    Messages:
    102
    Likes:
    6
    Hi,

    I would like to ask if methylfolate and methylcobalamin have to be taken at same time (or close time) or it's not important when you choose to take them during the day

    Thanks


    Daniele
     
  2. adreno

    adreno Learned helplessness

    Messages:
    3,569
    Likes:
    4,185
    Europe
  3. ahmo

    ahmo Senior Member

    Messages:
    2,777
    Likes:
    3,030
    Northcoast NSW, Australia
    Good idea to take close to each other. Here's something from Freddd. My understanding when he refers to 'one tablet' is B12.

     
    sregan and Hanna like this.
  4. daniariete2000

    daniariete2000 Senior Member

    Messages:
    102
    Likes:
    6
    Not sure 100% , maybe Fredd can answer to this question ?
     
  5. daniariete2000

    daniariete2000 Senior Member

    Messages:
    102
    Likes:
    6
    Found this answer of Fredd...so I ask : if Fredd write "methylfolate orally reaching a serum peak in an hour and sublingual b12 that is absorbed noticeably in 5 minutes"....is not better to take sublingual b12 after 1 hour of methylfolate when it reach its serum peak ?

    Thanks



    important to supply methylcobalamin first before methylfolate to prevent methyl trapping

    There is no need at all except maybe the very first dose of sublingual b12 only. And as I take methylfolate orally reaching a serum peak in an hour and sublingual b12 that is absorbed noticeably in 5 minutes when I was deficient or 30 minutes in the CNS there really isn't a problem. I have found that having the methylfolate on board while absorbing most of the b12 vastly increases the serum halflife. When in partial methylation block via folic acid b12 excretion via urine is very rapid. When in methyltrap, it is much much much faster. When in full methylfolate sufficiency serum half life is far longer then with folic acid. This is visible in the urine if one is taking large enough doses.

    Methylfolate is best absorbed on an empty stomach or sublingually

    I've never tried it sublingually. I take it on an empty stomach to avoid potassium and vitamin C which hinder it, and it is absorbed well.. It is said to be very well absorbed orally with food. I take my first dose of folate on empty stomach in morning with pre-meal supplements (LCF, SAM-e, DHEA, Pregnenolone and my meds). Then my first dose of AdoCbl/MeCbl after my first cup of coffee. Then I eat near noon my first meal. The methylfolate substantially increases retention of MeCbl in some way for some reason. In the evening I eat, wait two hours, take folate and then evening dose of b12, then an hour or more later potassium at bedtime.

    I take a full assortment of vitamins except folate and b12 at each of 2 meals.

    Somewhere in the afternoon I take a dose of methylfolate and then an hour or so later, potassium.

    This works for me.

    I'm finding that the first MeCbl-AdoCbl (10mg and 10mg, 5 star, 100mg MeCbl 3-4 star for 1-2 hours retention) an hour after SAM-e and LCF gets the neurological healing going, which is often not pleasant as it can cause irritation and anger if certain areas are damaged. I've been through several cycles of this.

    I don't always get the timing perfect due to living a life and having other things to do. I just do the best I can.
     
    sregan likes this.

See more popular forum discussions.

Share This Page