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Methylcolbalamin and Adensylcobalamin at Same Time?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by xks201, May 16, 2014.

  1. xks201

    xks201 Senior Member

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    Taking these 2 b12 derivatives at the same time would cause competitive inhibition, would it not? I would think they would possibly compete for the same receptor making taking both at the same time useless.
     
  2. PeterPositive

    PeterPositive Senior Member

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    Where did you find evidence that they cause "competitive inhibition"?
    As far as I understand it, they don't.

    If you take any other form of non-active B12s such as Cyano-B12 or Hydroxy-B12 you will transform them into their active forms (unless there are methylation or enzymatic problems), so there doesn't seem to be much of a difference, and they would still compete. Only you're adding them directly instead of producing them from the inactive forms.

    From what I have learned here and from other sources taking both forms of active B12 should be the best idea to refill your B12 tank, so to speak :)

    Also, most of the active B complexes I have used did have both forms.
     
  3. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    Competitive inhibition in this case is not really an issue. Yes, they might compete sometimes, but these have slightly different functions. Further, if they compete then a molecule is saved to work somewhere else. When the body permits competitive inhibit, and by permit I mean its evolved to not prevent it, then its often a good thing.
     
  4. xks201

    xks201 Senior Member

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    I didn't say I had proof they did compete I was just asking if anyone knew if they did or not.
     
  5. caledonia

    caledonia

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    Cincinnati, OH, USA
    I would actually call them complementary and not competitive. Methylcobalamin is required for methylation, and adenosylcobalamin helps the mitochondria and thus energy - something we can all use more of.
     

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