Thanks for the report, Rich. A two year followup is very interesting. As a bystander I have benefitted from watching and waiting this entire time, concluding that the mainstays are active folate and hydroxy b12, most likely, and figuring that I will need very tiny doses. For me it could only be a piece of the puzzle given chronic lyme. We need a better way to treat that. There seem to be small stepwise strides in understanding--as to why there is antibiotic resistance (biofilm communities which have been demonstrated in the lab) for instance. It would be nice to know why Luft's (Stonybrook scientist) virulent strain *is* virulent as opposed to mild nonprogressing strains. But every puzzle piece is worth it.