Freddd, please understand this post is too long for me to concentrate on fully (I'm revising a book at this very moment.) However, having skimmed it (and therefore perhaps wrongly) I think I'll still say you consider startup various effects that occur while getting b'12s "on board" as you put it in the process of healing the organism. Your assumption is that b12's, the active forms, are an unalloyed good in the patient population you are addressing here on this forum which is very heterogenous. My assumption is that some people will do well and need these b12s, some need one some need both and some don't do well and never will and do not need them. I think you need to incorporate that assumption into your overall worldview. I understand you are a layperson, not a scientist, not an institute, and not a doctor who can order the kind of tests that for instance Yasko specializes in. Therefore you can only offer your best hand, your best guess. I find some of your reporting questionable (as in my questions about your "N" a lot of which turned out to be people you met only once). I don't find evidence for your glutathione as a methyl-b-12 killer so to speak, reasonable. If I had time I'd pass it on to Dr Deth for his much more brilliant and considered opinion but I just don't. So the upshot is four people on this forum had dreadful responses to the active b12's. That just needs to be stated as a risk and possible side effect, and one needs to realize that not everybody who is sick needs active b12's. You were remarkably healed and others posting are having good results which is great. But it's not uniform. That's all I can say. Now gotta get back to work. Thanks. Apologies in advance for not reading the whole long posting in detail I just don't have it in me.