Hi Jimk, If you want I will walk you through these things and help identify the problems, starting at the beginning so I know where we are. At this point it could be all sorts of things lacking. It would mean taking your program to a known state and then eliminating the problems, such as not enough potassium and not enough metafolin. Those of us with paradoxical folate deficiency might need anywhere from 7500mcg to 30,000mcg of metafolin to overcome the paradoxical folate deficiency. That alone could account for many of you symptoms.