Hello all: I know this question has been asked here before but I'm looking for some help. I am MTHFR compound heterozygous have several MTR/MTRR mutations and no COMT mutations. I am also MAOa +. I deal with some fatigue and problems like tingling etc. But my biggest problems are anxiety, depression, memory and brain fog problems. Almost like my brain is too slow to process what is going on around me. In the past I have done a lot of detoxing with ozone, saunas and have a very good diet. Over the past few years I have tried phosphatidylcholine and acetyl-l-carnatine. Both made me very stimulated and gave me quite a bit of anxiety. I obviously stopped both. I repeated this again and had the same reaction. I also tried taking Inositol, taurine and l theanine to help with my moods and anxiety and had a similar reaction. Increased anxiety, agitation and overstimulation. I am on thyroid t3/t4 and low dose cortef. I've been tested for metals and don't have any significant levels also don't have any fillings. I'm 27 by the way. So finally here we go..... Last Friday I worked up the nerve to start taking Methylb12 (I have low b12 levels by the way) and Methylfolate. I started with 500mcg b12 and 400mcg mfolate. -Saturday I felt okay and upped my dose to 1mg b12 and 800mcg mfolate. -Sunday I felt quite good, had quite a bit of energy and a lot of motivation at work, I was just go, go, go. -Monday started feeling slightly depressed, took 1.5 mgb12 and 1200mcg mfolate. -Tuesday very depressed, very badly. At supper I took 2 mg b12 and 1600mcg mfolate. Within 20 mins, my depression had lifted and I felt very calm and nice. -Wednesday mood was good felt a little edgy and was feeling some strong emotions and got quite nostalgic and felt some regret. Stayed at the same dosages as Tuesday. -Thursday woke up felt quite anxious. Got to work at noon and was very anxious... totally on the edge... by about 2:30/3:00 I calmed down and was pretty much fine. I felt good for most of the day but I was really motivated all day, had tones of energy... felt overstimulated almost like I was on drugs and felt this way until I went to bed at 4 in the morning. (I was out with friends late) Felt very confident, very good, almost euphoric like. *Didn't take a dose of mfolate or b12 was kinda scared off of it. What in the world is going on??? My potassium is good I've been on top of that. -I have no COMT can this still be overmethylation??? -Is it possible that my brain is so deficient in neurotransmitters that since they've come up with the supplements my brain just got overloaded. (almost like starting an anti-depressant perhaps?) Could that explain why I've had reactions to the other supplements I've tried that supposedly affect neurotransmitter levels? -I'm determined to get this figured out. any suggestions????