Thanks
@caledonia - I've been through the heartfixer site and think that the order of issues would be:
1. AHCY - I'm double homozygous for 2 of the 3 AHCY genes and had a "no call" on the third. I think this is my primary methylation issue as AHCY is the only path for synthesis of Homocysteine (with Adenosine as a by product). As far as i can see this is the only way the body makes Homocysteine and i'm going to be doing that slowly. This would also give me reduced levels of Adenosine which could result in fatigue (I have this) and lowered immunity (i also have this).
2. CBS - I'm double heterozygous for CBS and this is an upregulation SNP. Usually this is considered a primary issue as it shunts too much Homocysteine through the Ammonia / Sulphation path, but as i'm slow at producing Homocysteine because of the AHCY, the CBS mutation is somewhat mitigated. To the extent that a CBS upregulation is doing this I'm probably pulling BH4 away from neurotransmitter synthesis to break down the excess ammonia. This would mean I'm slow to produce Serotonin and Dopamine (i have depression and have been on anti depressants for 5 years) so that looks possible.
3. MAOA - I'm homozygous (equivalent) for MAOA297R (and for 3 of the other MAOA SNP's). This would mean i'm very slow to break down Serotonin & Dopamine and one symptom would be a temper (yep!). However - because of the CBS pulling BH4 away from the creation of Serotonin - and I also have SNP's on DDC, VDR and TPH - I'm likely to be slow to produce Dopamine and Serotonin. Hard to interpret this but if i had to, i'd assume that as long as my serotonin and dopamine are in balance, I'm fine, but going either way on either (too much or too little) will be a problem as my ability to increase and reduce both are slow - so mood swings (also tick).
4. MTHFR C677T - This is needed to complete the conversion of THF to 5-MTHF and I'm slow at doing this. This is needed for 2 things:
a. Break down Homocysteine, not so much of an issue as the AHCY means i'm slow to produce that and CBS grabs what i do produce, so probably mitigated,
b. Creation of BH4 as a by product in reverse - more of an issue as BH4 is being taken through the CBS route to break down ammonia. Not mitigated as this probably works with the CBS mutation to reduce my production of neurotransmitters.
5. COMT & VDR - See the end of comment 3. My ability to make and break down Dopamine & NorEpinephrine are compromised, but probably this is less of an issue than it might be as I'm slow to create these due to a lack of BH4.
I'd really like someone with more knowledge and experience than me to confirm or correct me on any of the above if possible.