I'm in the low and slow crowd. The reasons are as follows: *Many supplements cause excitoxicity, even with a tiny dose. *I have multiple genetic issues to work around (compound heterozygous MTHFR C677T and A1298C for starters) *I have to work, so I can't be laid up with terrible side effects (which might be considered detox by some) *My liver HURTS and fatigue gets worse when I push supplements Here is a list of supplements I can't tolerate AT ALL, not even low and slow (many are the very items I need for methylation) *SAM-e, TMG, methionine, l-carnitine fumarate, milk thistle, B-complex of any kind (even the ones without folic acid), multivitamins. Improvements so far (I think due to Methyl B12 and Methylfolate primarily). *More tolerance for stress. *Periods of better sleep. *Less swings in energy and mood. Not Improved *fatigue *brain fog Now, correct me if I'm wrong, Freddd and Rich, but I believe that my liver seems to be at the center of my roadblock. I thought it was primarily my adrenals in the past, but I always have more energy in the morning. By afternoon, I fade. Every time I try to add methylation supplements or liver aids, I get horrible liver congestion and worse fatigue. It does not go away or recede unless I remove the offending item completely. My question is, how can I get my liver cleared of years of congestion before continuing the protocol? Other ideas? I have read about Chinese bitters and other such tonics, but I don't know if this would react just like milk thistle and make my problem worse. Does anyone else out there think that your liver is holding you back?