Hi guys, firstly a big hello to everyone here, thank you all for your input. This is my first post, I have been lurking in the background on this forum for sometime trying to gather as much information as possible to help me with my situation. For the past 6 years I have suffered mild fatigue alongside a burning pain in my bladder, isspect this is caused by mast cell dysfunction due to low BH4. In addition I have always suffered with mood and concentration issues, I was diagnosed as ADD when i was 14. The past 6 years of tests and research has led me to investigate my genetics and methylation cycle function. This week received my methylation panel from ELN. Having looked over the panel with the help of Rich's methylation panel interpretation its seems that I have a methylation cycle block.
I had planned to start with my CBS upregualtion addressing ammonia, sulphur and going low protein. I am a little confused though as most people with CBS upregualtion have low homocysteine, mine is very high at 13.1 umol/l. I'm assuming that is high as the rest of the cycle is running very slow? Markers that indicate that CBS is a problem for me include high ammonia, high taurine, low citrulline, decreased methionine, elevated hippuric, decreased fumerate, low manganese and low molybenum. My urine sulfate sticks have me at around between 800 and 1200, indicating that I am producing too much sulfate another sign of CBS upregulaion. I also produced a lot of hydrogen sulphide as indicated by he Protea Biopharma test.
If anyone could give me any tips ect based on my results that would be greatly appreciated
Many thanks
Rhys
I had planned to start with my CBS upregualtion addressing ammonia, sulphur and going low protein. I am a little confused though as most people with CBS upregualtion have low homocysteine, mine is very high at 13.1 umol/l. I'm assuming that is high as the rest of the cycle is running very slow? Markers that indicate that CBS is a problem for me include high ammonia, high taurine, low citrulline, decreased methionine, elevated hippuric, decreased fumerate, low manganese and low molybenum. My urine sulfate sticks have me at around between 800 and 1200, indicating that I am producing too much sulfate another sign of CBS upregulaion. I also produced a lot of hydrogen sulphide as indicated by he Protea Biopharma test.
If anyone could give me any tips ect based on my results that would be greatly appreciated
Many thanks
Rhys