I’ve recently increased my methylation up to following: 7.2 mg methylfolate and 70 mg of methylcobalamin (sublingual) daily divided up into three doses. Is this the right kind of folate to B12 ratio? Are my B12 levels too high? Should I divide them into more than 3 doses? Why does B12 successfully treat my anxiety disorder and my knee pain? It is better than any antidepressant and painkiller – and I’ve tried a few! Note I also take one adenosylB12 daily and all the other cofactors that Freddd suggests except Sam-e which I couldn’t tolerate. No injections. Thanks for your advice!