Thanks Freddd, - is this deadlock quartet appropriate regardless of my gene mutations in MAO VDRTAQ and COMT?
Or is this deadlock quartet therapy applicable to just anyone who has serotonin deficiencies?
The Deadlock Quartet is appropriate for the people with the following symptoms in my opinion. I work with symptoms that of course include all the influence of all the genes whether specified or not. Just last week a study was published showing that Schizophrenia is affected by 170 genes or thereabouts. I don't think that picking 3 genes out of quantities like that for a disorder has much predictive value. I have yet to see anybody get well by treating to gene interpretations. The knowledge isn't here yet.
SYMPTOMS LIST 01/03/2014 V 1.0
In this post this is a list of symptoms that are mine, and others experience of these nutritional items in relieving their symptoms, and in a very few instances reflect research and successful practice, such as p5p for Hcy and Liver extract studies of several disorders in old journals. In some instances the same symptoms might have different combinations of nutrients.
These symptoms responded almost entirely or entirely with
basics 5 star MeCbl – methylcobalamin – Methylb12 - Mb12 - Mecobl . Many started improving in hours. Others took 9 months to correct.
morning joint stiffness and painpalenessacid refluxnauseadaily vomitingstanding with eyes closed, lose balancehands feel gloved with loss of sensitivity - glove anesthesiafeet feel socked by loss of sensitivity - stocking anesthesiaglove and stocking anesthesianeuropathic bladderunable to release bladder, mild to severeunable to fully empty the bladderfecal incontinence - occasionally to frequentlydiminished hearing - gradual onset or present for life, sudden return possibletinnitus - ringing in earsalways feeling coldintolerance to loud soundsintolerance to multiple soundssleep disordersnon restorative sleepNight terrorsProlonged hypnagogic or hypnopompic states transitioning to/from sleepSleep paralysisalteration of touch all over body, normal touch can be unpleasant and painfulalterations and loss of tastetaste hallucinationssmell hallucinationssound hallucinationsvisual hallucinationsalterations and loss of smellloss of smell and taste of strawberries specificallyloss or alteration of smell and taste of potato chips specificallyroughening and increased raspiness of voice, mb12 can smooth in mid wordblurring of vision - can be sudden onset and sudden returnVisual impairment can be seen; ophthalmological exam may show bilateral visual lossoptic atrophycentrocecal scotomatahypersensitivity/intolerance to bright lightintolerance to loud soundsintolerance to multiple soundsburning muscle paindiminished hearing - gradual onset or present for life, sudden return possibletinnitus - ringing in earssore burning tongue
This is a list of symptoms that are mine, and others experience of these nutritional items in relieving their symptoms, and in a very few instances reflect research and successful practice, such as p5p for Hcy and Liver extract studies of several disorders in old journals. In some instances the same symptoms might have different combinations of nutrients.
These symptoms responded strongly first to 5 star MeCbl and then Metafolin with basics. Many started improving in hours. Some took 7 years to correct.
Bursitisstomach not emptyingfrequent vomitingacid regurgitationdyspepsia flatulencealtered bowel habitsabdominal painloss of appetite for meat, fish, eggs, dairy, the only b12 containing foods nutrient specific anorexiaintermittent constipationintermittent diarrheairritable bowel syndromesores, ulcers and lesions along entire GI tract or any partanorexiaBulimiaHypersensitivity to touchHypersensitivity to odorsHypersensitivity to tastesHypersensitivity to clothing textureHypersensitivity to body malfunctions, symptomsHypersensitivity to sounds and noisesHypersensitivity to light and visual stimuliHypersensitivity to blood sugar changesHypersensitivity to internal metabolic changesHypersensitivity to temperature changesburning bladder (no UTI)painful urgency (no UTI)burning urethra (no UTI)Low blood serum level - below 550pg/ml, Japanese Standardelevated MCH (Mean Corpuscular Hemoglobin)elevated LDHbig fat red cells (when said this way usually with happy or healthy modifying it completely misinterpreting results of MCVplatelet dysfunction, low countwhite cell changes, low counthyper segmented neutrophilsheadachesinflamed epithelial tissues - mucous membranes, skin, GI, vaginal, lungsinflamed endothelial tissues - lining of veins and arteriesmucous becomes thick, jellied and stickyasthmachronic cough that mimics asthma but isn'tchronic sinus congestiondermatitis herpetiformis, chronic intensely burning itching rashfrequent infected follicles or acne type lesions all over bodychronic infections, many varieties possibleSeborrhic dermatitisdandruffeczemadermatitisskin on face, hands, feet, turns brown or yellow if anemia occurspoor hair conditionthin nailstransverse ridges on nails, can happen as healing startsmouth sensitive to hot and cold sore burning tonguebeef-red tongue, possibly smoother than normalsore mouth, no infection or apparant reasonteeth sensitive to hot and coldcanker sores
with p5p added
Elevated blood serum Hcy, borderline or higher
These symptoms responded relatively partially first to 5 star MeCbl and then very strongly to Metafolin with basics. Many started improving in hours. Some took 7 years to correct.
splits/sores at corners of mouth -angular cheilitis
impaired white blood cell response
poor resistance to infections
easy bruising
pronounced anemia
macrocytic anemia
megablastic anemia
pernicious anemia
decreased blood clotting
MCV > 93 first warning,
MCV > 97 alert
MCV > 100 outright macrocytosis
MCV > 105 urgently needs treatment, severe problem
Plus Vitamin EChild with neural tube defects
mother of child with neural tube defect
These symptoms responded not at all first to 5 star and then very strongly to Metafolin with basics. Many started improving in hours. Some took 7 years to correct.
lack of dreaming MCV > 100 outright macrocytosismacrocytic anemia
metallic taste in mouth
Widespread body & muscle pain responding to NSAID
Joint pain responding to NSAIDSsplits/sores at corners of mouth -angular cheilitis
Sexual related symptoms, both men and women – These responded with the most response to lesser responses in order to MeCbl, Metafolin (l-methylfolate), AdoCbl, L-carnitine fumarate
reduced libido - loss of sexual desire
loss of orgasmic intensity
unsatisfying orgasms
inability to orgasm
loss and/or change of genital sensations
burning genital skin sensation
unable to feel aroused
numb genital skin
low sex hormones
MEN
In order of response – MeCbl, AdoCbl
low testosterone men
In order of response – MeCbl, Metafolin, AdoCbl, L-carnitine fumarate
erectile disfunction men
In order of response – MeCbl, Metafolin, AdoCbl
low sperm count
poor sperm motility
Poor sperm quality
no sperm
WOMEN
In order of response – MeCbl, AdoCbl
low testosterone
low estrogen
In order of response – MeCbl, Metafolin, AdoCbl, L-carnitine fumarate
post partum depression
post partum psychosis
In order of response – MeCbl, Metafolin, AdoCbl
Frequent miscarriage
In order of response – MeCbl, Metafolin
False positive pap smears, defective cells
menstrual symptoms
Approximate timing of my startup of individual items that being considered here, this gives a quite distinctive pattern for each nutrient or set of nutrients: 03/04/13, Version 1.1
Others mentioned similar patterns and variations.
1.Initially – Mecbl
2.+5 months 400mcg SAM-E
3.+ 4 months AdoCbl
4.+ 3 months titrate +50mg zinc
5.+4 years 400mcg Metafolin
6.+1 year LCF
7.+ 1 month TMG 1000mg/day
8.30mg MeCbl injections (3 or 4) daily,
9.+0 Reduce SAM-e to 200mcg
10.+ 4 years remove TMG
11.+6 months increase SAM-E to 800mcg
12.Next 1 year titrating Metafolin and finding all the reasons I get folate insufficiency, early partial methylation block by effect.
These symptoms are what responded very well to CNS penetrating doses of MeCbl either as 50mg sublingual single 4-5 hour dose or 4 x 7.5mg or 3 x 10mg or for some 2 x 15mg subcutaneous MeCbl injections. Metafolin in some way enhances retention of AdoCbl and MeCbl with excretion visibly decreased. A sublingual dose of 1-2 tablets each hour added for 12 hours appears to generate substantial CNS penetration as well.
CNS penetrating dose MeCbl – AdoCbl – Metafolin – Omega-3 oils
Elevated CSF Hcy
Low CSF cobalamin
limbs feel stiff
Drowsy
CNS penetrating dose MeCbl – AdoCbl
dimmed vision - usually not noticed going into it because change can be very slow or present for life
Clumsiness
CNS penetrating dose MeCbl – AdoCbl - Metafolin
Slow to adapt to night vision
CNS penetrating dose MeCbl – AdoCbl – Metafolin – LCF
Difficulty in word finding
CNS penetrating dose MeCbl – AdoCbl – Metafolin – Omega-3 oils
Brainstem or cerebellar signs or even reversible (with mb12) coma may occur
demyelinated areas on nerves
subacute combined degeneration
axonal degeneration of spinal cord
unsteadiness of gait
ataxic gait, particularly in dark
positive Romberg
positive Lhermittes
Loss of motor control over some or all of toes
Loss of motor control over part or all of feet
Loss of sense of joint position
sudden electric like shocks/pains shooting down arms, body, legs shooting down from neck movement
sudden "ice pick" pain
decreased reflexes
brisk reflexes
Foot Drop
tripping over toes
injuring toes catching top of toes on floor
general feeling of weakness
Approximate timing of my startup of individual items that being considered here, this gives a quite distinctive pattern for each nutrient or set of nutrients: 03/04/13 Version 1.1
Others mentioned similar patterns and variations.
1.Initially – Mecbl
2.+5 months 400mcg SAM-E
3.+ 4 months AdoCbl
4.+ 3 months titrate +50mg zinc
5.+4 years 400mcg Metafolin
6.+1 year LCF
7.+ 1 month TMG 1000mg/day
8.30mg MeCbl injections (3 or 4) daily,
9.+0 Reduce SAM-e to 200mcg
10.+ 4 years remove TMG
11.+6 months increase SAM-E to 800mcg
12.Next 1 year titrating Metafolin and finding all the reasons I get folate insufficiency, early partial methylation block by effect.
These symptoms are what responded very well to L-carnitine fumarate AND AdoCbl for the first two items
L-carnitine fumarate – AdoCbl – Metafolin - MeCbl
weight loss involuntary
muscular atrophy
exercise does not build muscle
L-carnitine fumarate – Metafolin – AdoCbl - MeCbl
weight gain, watery fat
edema
L-carnitine fumarate – AdoCbl – MeCbl – Metafolin
mild to extremely severe fatigue
continuous extremely severe fatigue
easy fatigability
severe abnormal muscle fatigue up to and including apparent paralysis leading to deathweakness
muscle pain especially around attachment points to bones
Eighteen severely tender muscle spots of FMS
AdoCbl – L-carnitine fumarate
exercise debilitates for up to a week, making things much worse
accumulating muscle pains following exertion
sore muscles throughout body
lack of muscle recovery after exercise
High urinary MMA
AdoCbl – L-carnitine fumarate – Metafolin
congestive heart failure
Elevated CSF MMA
Elevated uMMA
Approximate timing of my startup of individual items that being considered here, this gives a quite distinctive pattern for each nutrient or set of nutrients: 03/05/13, Version 1.1
Others mentioned similar patterns and variations.
1.Initially – Mecbl
2.+5 months 400mcg SAM-E
3.+ 4 months AdoCbl
4.+ 3 months titrate +50mg zinc
5.+4 years 400mcg Metafolin
6.+1 year LCF
7.+ 1 month TMG 1000mg/day
8.30mg MeCbl injections (3 or 4) daily,
9.+0 Reduce SAM-e to 200mcg
10.+ 4 years remove TMG
11.+6 months increase SAM-E to 800mcg
12.Next 1 year titrating Metafolin and finding all the reasons I get folate insufficiency, early partial methylation block by effect.
MeCbl - AdoCbl – L-carnitine fumarate – Metafolin
shortness of breath, oxygen hungerheart palpitations
MeCbl - AdoCbl – L-carnitine fumarate
extremely sore neck muscles reversing normal curvature of neck
painfully tight, stiff muscles, especially legs and arms
frequent muscle spasms anywhere in body
weak pulse
MeCbl - AdoCbl
Confusion
Disorientation
Difficulty in word finding
MeCbl - AdoCbl - Metafolin
irritable
depression
SAD - Seasonal Affective Disorder
mental slowing
personality changes
chronic malaise
poor concentration
moodiness
tiredness
mood swings
memory loss
listlessness
impaired connection to others
mentally fuzzy, foggy, brainfog
dizziness - even unable to walk
Vertigo
MeCbl – Metafolin – AdoCbl – L-carnitine fumarate
psychosis, including many of the most florid psychoses seen in literature, megaloblastic madness
Alzheimer's
delirium
dementia
paranoia
delusions
hallucinations - multisensory
anxiety or tension
nervousness
mania
Widespread pain throughout body
A caution, those with anxiety and panic symptoms may respond with extreme moods of increased fear, anxiety, panic, anger rage, homicidal rage and profound depression, usually in repeatable sequences following LCF or ALCAR even at levels of 1mg oral. A micro titration of carnitine would be cautious. While most find the moods intolerable, certain persons have been able to tolerate these (both past) and current, to find they can fade after some months of consumption. A few people may find similar, maybe somewhat lesser, response to MeCbl or more likely AdoCbl. As these are less controllable than LCF which can be micro dosed, they should be considered first.