Raven & CPU, I do take a multi b. don't really feel it make a difference like b2 . The one consistent aspect during this process is that when your system gets moving fast you burn out on many elements in the cycle. B2 helps store all the other bs and after 4 week on the protocol my body ran out of b2, and the whole methly process stopped. I also got eye floater. Increased my b2, it solved the problem. I solve one symptom at a time, never saw a need for manganes. Your body will tell what it's missing. Over the past 6 months I have posted symptoms that need to be addressed and someone on the board solves it. Collectively the people on this board have a vast amount of knowledge.