Hi Cureminded, But how do you know for example that it's better for you to take 12 g of vitamin C a day instead of 4, 6 or even 8 g? I'm simply afraid to overdo it, but than again I'm worried that I'l miss the signs and won't take enough of what's lacking. Do you take an Ester C by the way? I thought regular vitamin C can cause stomach problems due to high acidity. 12 g must cause a lot of acidity. I determined my vit C dose the same way I determined the dose of everything else that provides a noticable benefit. Some things like calcium and magnesium, vit E and Lecithin, omega3 and selenium, I take according to a variety of theories, package instructions and so on. The things that produce noticable changes I take according to titration. That is how I came up with mb12,adb12, metafolin, potassium, some of the B separates and complex. I also am constantly re-evaluating. I get a variety of blood tests, in several combinations, each 6 months. I try to sort out the various things with my doctor and all sorts of ideas from people here and elsewhere. It was somebody on this forum that told me about Metafolin counteracting NAC and glutathione "detox" in a large enough dose, and B2. It was somebody on another forum that told be about the potassium and zinc and pantethine. I started vitamin C at 1 gram a day way back when my M-I-L, a long time PREVENTION reader, suggested vitamins to me to deal with my problems. Look at all my M-I-L stirred up. When I got up to 2000mg a day, my untreatable UTI of 2 years duration went away. When I got up to 4000mg a day the 6 streps per year plus pneumoinia every few years went away. When I got up to 16,000mg a day, the swollen glands of 15 years duration went away. After starting the mb12 and all that I decided to re-titrate as I was now much healthier. I went back down to 6000mg/day. In 5 years the perpetual swollen glands came back, I started getting colds and flu again (2 in two years, 4 in 8 years). I titrated upwards again and it took 12,000mg/day to normalize them again but is too early to tell about the colds and flu. I have no stomach problems with it and take the Costco Kirkland Vit C with bioflavinoids 1000mg. I couldn't begin to afford Ester C and see no need to do so. It's funny (well not funny, but interesting I guess) how you mentioned that your personality changed so much that though your marriage held up through your disease, but it didn't survive you getting better because your personality has changed so much. I'm very curious to see what's going to happen to me, since I feel that there's been a lot of change in my personality and I'm hoping that that can be corrected The personality changes weere from all sorts of reasons. The deficiencies did a job on me. At another forum the deficiency effect was called "Mr Hyde" and the non-deficiency state "Dr Jeckyl. Here, in dealing with some very specific thing it became clear that Mr Hyde was very much connected with limbic system b12 deficiency and then starting up the damaged limbic system made it worse for a while. I also am a Tantric Alchemist and did extensive inner spiritual work which didn't do much until I started healing and those changes hit all at once. Also I had a couple of dozen NDE experiences, some detailed over on one of the spiritual threads, several of which culminated with my return into this body as a thoroughly different person, literally in a matter of minutes. Also, as I generally healed I got more assertive and started sticking up for myself. One thing I have told people about all this is while many mood and personality changes do occur due to the biochemistry, that doesn't undo decades of experience. A lot of things can't be "un-done" but rather have to be enlarged upon and rebalanced. There is approximately zero probability that I will return to my early illness personaility that developed from birth until the acute phase happened at age 39. Whatever I am now is a new synthesis, not a return to something previous. People with paradoxical folate deficiency and genetic causes, whatever they are, of the active b12 deficiencies, don't have a former b12 and folate sufficient state to return to in any case. Another qestion I have, since you have kids. Do you have any advice as to what I should be supplementing my 1,5 year old son? I'm worried that he might have inherited some of my genetics and deficienciesin methylation, etc. (if I have these, which I think I do). I give hime Solgar kangavites multi. Planning to add C kangavites as well and Solgar has a fish oil supplement for kids that I want to give him. That's not optimal I guess, but it's the best I can come up with for one that can't and won't swallow pills. We gave our kids liquid vitamins but then the Metafolin and mb12 and adb12 were not avaialble. A friend gave her daughter a decent children's gummy vitamins with sublingual tablet pieces that her daughter sucked and chewed and always a larger dose before and after all vaccinations. Thanks for clarifying. I tried to swallow the pills during breakfast and not right after and realized that it helps. I realized also that milk somehow works better than water. Feels smoother somehow. Not sure whether that's beneficial for the uptake though. The advice I read that works is to eat 1/4 of the meal, take alternating pills and bites of food for the middle half and 1/4 on top. To avoid stomach upset I need a mix fo foods, too much protein such as meat or eggs alone and I vomit as do others. DISCLAIMER I am a self taught systems analyst and consultant. I am not credentialed, certified or licensed to do anything besides drive a car. I have been disabled by the disease processes being discussed and affecting neurology in a multitude of ways for 10 years and impaired in a variety of ways and levels for 54 years before that. Everything I say is my opinion, synthesis, understanding or otherwise of my own creation except direct attributed quotes. Approximate paraphrases are also my interpretation of what I have read. All of this is at best my data analysis, understanding, synthesis and hypotheses and not to be construed as medical advice. I am not responsible for anything you do with any information provided in any way. Anything you do is your own responsibility and at your own risk. There are no published peer reviewed studies backing up my opinions or statements, except the incidental ones quoted or implicit in my synthesis or understanding, and then only in so far any reading of such papers may confer. Your interpretations, actions and variations of what I say are strictly at your own risk.