Over 3 years, with careful diet and supplement work and graded exercise... I have improved from severe AFS (adrenal fatigue syndrome) / CFS to mild CFS symptoms These days, I'm feeling more good than bad. I currently have excellent sleep and great cognitive function.. few symptoms.. unless I overdo it... then I get PEM, fibro pain, sleep problems.. which clear up after a day or two of taking it easy.. But with careful rest and pacing, I feel good most of the time. I work almost full time but I still suffer from not being able to live a normal life, make friendships and dating and feel like I'm on "house arrest" on the weekends. I currently take Energy Revitalization System (multivitamin containing folic acid & cyano), d-ribose and thyroid glandular. It works to boost but doesn't seem to fundamentally cottect the underlying cellular dysfunction. Does a methylation protocol sound like a good fit for my mild CFS or is it only for very sick people? Thank you very much for reading and/ or responding.