The title of this thread may be contradictory. The subject is complicated. At least I think it is. But many of the forum members talk about lifting methylation blocks as if they were exchanging some cookie-dough recipe. Are you all Einsteins? Or biochemists? In the last 2 years I have been reading a lot on this forum and elsewhere about the various methylation protocols. Because of the many positive reports I have tried different recommendations. Without results or any reaction at all unfortunately. But frankly the more I read about this subject the more confused I get. There are so many conflicting theories and protocols and revised protocols and addendums out there. It is impossible to know where to start for newbies. And if you delve in to all the underlying biochemistry, genetic mutations, etc. It all gets extremely complicated and it is just way over my head. Yes you can just point me to one of the many threads that are already there. Believe me I have read them all. And because of reading them all it is impossible to make a well informed choice. There is just too much contradiction. Can anybody recommend what protocol to try, based upon the latest insights. What kind of B12, what form, what brand, how much. same for Folate. If nothing happens, what should be added? Or do I need to have tests done before this can be answered? Can this be done under medical supervision? Perhaps over the internet? (I am homebound). Or what would be a reasonable relatively safe protocol to start with?