Per my previous posts, I've taken a Methylation Pathway Panel, which showed a classical methylation block as described by RichVank - depleted GSH, high GSSG, low SAMe, etc. I had a Spectracell vitamin and mineral test before starting the SMP and one just recently, a year after starting the SMP. If you've never heard of Spectracell, its more of a functional test than a serum level test. They take your cells and grow them in media that is specifically deficient in one vitamin/mineral at a time and see how your cells grow. In the first test, I was deficient (totally in the red) in all B-vitamins. This result is what drove me find the Methylation Pathway Panel and this forum. In the second test mostly everything came up, all the B-vitamins, etc. Couple of interesting unexpected changes: my Zinc went from very normal to very deficient. Also Magnesium and Vitamin A went from very high to borderline. I'm trying to understand what would deplete specifically Zinc so much. Its been in normal levels in my multi for the past year. Zinc is a co-factor superoxide dismutase. It's possible that the glutathione systems are ramping up and using up the Zinc? My Copper levels didn't change. Has anyone else noticed this phenomenon?