Correct me if I am wrong, but doesn't this study just suggest that the caffeine is doing just what other stimulants do, they increase dopamine and stimulate methylation on a temporary basis. Does this really result in any net gains, and does this apply to a human with low glutathione. Obviously improvement in lipid peroxidation, SOD activity etc., is desirable; however, I wonder how well this translates to someone who has abnormal methylation capacity. In someone with low glutathione would this have any lasting consequence if they are not correcting the limiting factors. I would have to speculate that there is a consequence to this binge since glutathione resources are finite, and a temporary rise in brain concentration could result in deficits later. At least that is how I have always looked at it; everyone has finite resources, but ours are much more susceptible to the effects of stimulating energy.