I was about to order the Methylation Pathways Panel from European Laboratories (Health Diagnostics Europe) however they have quoted me 310 Euros (~$US 405). This is a pretty large bump from the original quotes I've seen here of $US 295. So this has prompted me to question the value of the test. I see its value as: A) Initial diagnosis - do I have a methylation issue? B) Progress tracking - this requires multiple tests (e.g. every 3 months) However, it does not in itself - currently - have any 'decision making' value. I.e. Modification of treatment. If you have the symptoms its still worth trying regardless of the methylation test output. DO OR NOT DO METHYLATION PROTOCOL DECISION = not valuable input: It seems that most people benefit from the simplified methylation protocol or Freddd's alternative protocol targeting the same mechanism. Unless you megadose as with Freddd's you are actually sticking pretty closely to general health optimization recommendations (i.e. B12 methylcobalmin, and 5MHTF are recommended for healthy individuals in 5000mcg/ 800mcg daily intakes by a lot of health public figures these days). So it should not do any harm, but has the possibility of an upside. Progress Tracking and Continuation or modification Decision = valuable, but at too high cost: It would be useful to do the panel every 3 months or more frequently, however at $400+ those costs are going to stack up pretty quickly. At this point - I'm probably going to go with other 'progress tracking' tests as a result - like the Yasko basics (UAA, UTM/UEE etc.). However, I have a lot more reading ahead of me before I get my head round all of this and really understand how each of the tests can provide input to decision making - i.e. changing treatment to get better results.