I've been asking on another thread about how to get the methylation panel because I thought that people were getting advice based on their results about how to tailor their supplements according to their specific problems. It just occurred to me that I might have misunderstood this and that the purpose of getting the test is simply to establish whether one has a partial methylation block and should just go on the standard protocol and then try to adjust it by trial and error. I'm already convinced I've got a partial methylation block problem because when I started Fred's protocol, I immediately got an energy surge (within half a minute) from ab12 which was sustained for several days; plus I had reproducible start-up symptoms (weird sensations and twitching in my face and sacro-iliac joints) and then a huge need for potassium and then extreme exhaustion and muscle soreness as what was presumably some sort of induced deficiency got beyond my ability to deal with. Fred has said that if you don't have b12 deficiencies you don't get any symptoms and I certainly had a load. So, do I actually need to do the methylation panel? I've been on Rich's SMP now for 10 weeks with no apparent effects (good or bad) and am thinking that if I need to tailor it, should I be getting the panel done to guide me? But would it?