Sushi recently informed me about the HDRI methylation and I was curious as to whether there were other options, or is this one the best one for the money? I did my own search and I found this one from integrative psychiatry called Methylation Test Profile. Has anyone here tried this one? The DDI Methylation profile evaluates the plasma levels of methionine, cysteine, SAM, SAH, Hcy, and cystathionine and provides the important “methylation index” (ratio of SAM to SAH). This one does not include the folates or the GSH/GSSG ratio, but it could be more convenient, as I have heard the HDRI takes quite awhile to get the result back.