Seems like there's a block going from Met -> SAM. I found this thread which had a lot of good info by @DREBS http://forums.phoenixrising.me/inde...thionine-yet-blocked-methylation-cycle.23785/ Apparently ATP and magnesium are the cofactors for Met -> SAM. I take loads of magnesium glycinate, it helps all my symptoms and helps my sleep so I don't think that's the problem. I did Genova's Nutreval and my krebs wasn't in great shape, so that might corroborate a low ATP hypothesis. http://imgur.com/pQLGBw2 http://imgur.com/uJmmBK6 Genova has an awesome interpretation guide for that and I've been following its suggestions. https://www.gdx.net/core/interpretive-guides/Organix-IG.pdf Does anyone have any other ideas, as to what might be the problem here?