I've started taking a 1/4 of a pill atp fuel. 5 pills is a full dose... I have been taking it for 1 week and am peeing about every hour and I am on fludrocortisone to help with salt and water retention. Middle twitches too. My bladder and kidneys are starting to hurt... Is this potassium issue? All my methylation attempts do this. I am an over methylator... Working on increasing my niacin now. I have increased potassium but can't seem to catch up... I've had such an issue with water retention since being sick. Any thoughts? I don't want to have to stop treatment again... I never get anywhere. I took 50mg time release niacin at lunch and 25 at supper. Never got a flush... Increasing it today. If I'm an over methylator... Proven by low blood histamine... Am I always over methylating even before starting methylation treatment? Should I be taking high doses of niacin every day? Should I focus on doing niacin and then add in atp fuel/methylation protocol?