I don't often consider all the little steps I have taken to get where I am today , learning about methylation was huge---but only another piece in the puzzle. Here are some of the things I applied. Most people who have methylation issues are likely experiencing gut issues as well and you will NOT heal until they are addressed. Parasites and H Pylori and very common and pretty easy to handle given the correct approach and some time. Afterward some L-glutamine to heal the damage and 6 months of a high quality probiotic. A more menacing problem imo is heavy metal intoxication. I used Dietrich Klinghardt's approach with Chlorella and Cilantro tincture. After quite some time I moved on to some of Cutler's methods and incorporated Lipoic acid and hopefully got rid of most of my holdings--- all this was after amalgam removal. To address any one issue without paying attention to the total load will improve one to a point but you will not attain vibrant health until all bases are covered. Gut health is huge as you can't heal if you can't assimilate nutrients.