It took me months of building up manganese, molybdenum, choline+inositol and TMG but I can finally tolerate methylfolate with tolerable side effects. Every time I tried taking it before, I got very tense shoulder muscles and too much inflammation from it, and had to stop after a couple days. The first week on methylfolate (400mcg quatrefolic/day) was a little rough with increased inflammation but it seems to have gone away. The best part is that my allergies are hugely improved, starting couple weeks after starting methylfolate, and taking supplemental SAM-e now makes me feel a little weird. I was able to shovel moldy cedar/spruce/pine woodchips, damp compost with heavy trichoderma sporing for hours without taking SAM-e or an antihistamine for the first time since I suddenly acquired my many allergies a few years ago. Now I'm having a problem with slowly wasting muscles and some associated fatigue. It's a little too early to say for sure yet, but I think it may be hypohomocysteine because: too much P5P makes it worse, and it also makes me sleep all day (didn't do that before). if i don't take some P5P biweekly or so, my muscles start to ache. I generally avoid P5P as much as possible so that I can tolerate thiol foods. methionine seems to alleviate it temporarily, but it makes me feel heavy in the liver so I've tried only small amounts. it's always made me feel like that but i can tolerate it a lot better than before since adding choline. I notice people often take methionine with TMG but I didn't, presumably for avoiding homocysteine depletion but never stated it gets worse with more methylfolate I haven't been able to find much information on this, but if anyone has any experience with this problem, I'm interested in how you dealt with it.