I have shmt +/+ along with other mutations. I hope someone can help. I planned to start supporting the shmt with lactoferrin, nucleotides and low dose folinic acid like Yasko suggests. I am very sensitive to supplements. Every time I start the methylation treatment I get prostate pain after about the 4th day. Maybe I just have to start as low dose as I can. My question is why the prostate pain and other symptoms? I would love any ideas or help. Thank you in advance. Here are my mutations.