Hello there, It’s my first post here as I’m looking for some help and advice with regards to the methylation protocols. I’m very new to all of this and am not fully familiar with the science behind the methylation cycle so any help, advice and tips would be greatly appreciated. I’ve been struggling with chronic fatigue along with depression and paranoia (health paranoia) for many years. Even as a child, I was very nervous and skinny. Every morning I wake up and feel like a zombie no matter how much sleep I get and am so depressed with brain fog and memory problems. I don’t have any issues with my nerves, no tingling, numbness, pain or anything like that. About two weeks ago, I purchased Thorne Basic B Complex which includes the B complex in their methylated forms. Within 3-4 days I had some AMAZING results - honestly life changing results - My depression had lifted, my brain fog was clearing, I actually felt happy and motivated and I felt that I had so much more energy and stamina in my muscles too (physical). I was running up and down the stairs, getting things done, had great motivation - it was honestly life changing. Colours seemed much more vivid, I was really appreciating the real world around me. Food tasted good, I was enjoying eating again. My night vision started to improve. I was really happy. Even my memory improved - I could remember the little things again. This lead me to trying to figure out why I felt so great - hence my discovery of the methylation cycle. I read Freddd’s protocol in detail, along with a couple of the others. I started taking Jarrow 5mg sublingual B12 along with the Thorne Activated B Complex. I still felt good, but ever since I increased my B12 dosage (I ended up taking 2x 5mg sublingual daily) I have crashed. I seem to have gone back to square one - back to being depressed, brain fog, extreme morning lethargy and all of the other symptoms. Is it possible that I have depleted my folate supply? When taking such high doses of B12, could it be the lack of folate causing the block now? Perhaps I should stop taking everything and go back to just taking the Thorne B Complex again? I remember that one night last week, I had SO MUCH energy - I felt like a million dollars and so happy then the following morning came the crash. I take: 5mg Methyl B12 twice daily Thorne Basic B Complex (which includes L-5-Methyltetrahydrofolate at 400mcg per capsule) twice daily Can anyone shed any light? What’s blocking the cycle?