Hi all, I'm just hoping to get some advise regarding methylation protocol dosages. I started the methylation protocol almost a year ago although I've had a few weeks off here and there due to severe side effects. I started very low and slow with a good multi then added in a B complex then added in the sublinguals of both B's and methylfolate plus the various showstoppers mentioned by Freddd (I spend a fortune on supplements!). I'm up to about 1600 mcg of methylfolate and 5000 of both B12s. I tried going to 2400 mfolate and 10,000 both b12s for a while (maybe 6 weeks) but it made no noticeable difference. My symptoms are terrible both on and off the methylation supps and either way I have a good 20-30 symptoms at any given time, i.e. headache, muscle and joint pain, flu symptoms, excessive thirst, burning nerve pain, extreme fatigue, sore glands, etc... (I won't bore you with the whole list). I get some additional symptoms on the supps like increased dizziness and POTS, excessive sweating (like sweating through layers of clothes), facial flushing and fast/strong pulse which is sometimes arrhythmic. I have tried to wait for these side effects to even out before increasing dosages but they never really do and a lot of people on here report similar reactions. Also I've tried to watch out for and keep on top of paradoxical folate problems and potassium and other electrolyte issues so I don't think its any of those. My question is - after a year on methyl supps why don't I feel better? I am doing something wrong? I am taking too much? Not enough? Is methylation something that often takes longer than a year to see benefits? I am taking more than Rich suggests but less than Freddd recommends which seemed like a good middle ground but now I wonder if I should either drop back down and try Rich's protocol or increase to Freddd's? Has anyone tried megadosing as Freddd suggests? I read a post by Rich recently that said too much b12 actually drops your glutathione and makes things worse, however, Freddd and others seem to feel that Rich's dosages aren't enough. When you consider that people with folate deficiency are given Deplin (7-15mg of mfolate) then taking Rich's amount doesn't seem enough. I know there is no one size fits all with this stuff but at the moment I don't want to go low have it do nothing and have to go through the start up again or go high and have worse reactions. Also I'm pretty worried about low potassium. Any and all advice would be greatly appreciated. Thankyou.