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Methylation calmness ?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by vortex, Jun 21, 2014.

  1. vortex

    vortex

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    I am up to 5 mg methylfolate and feeling a noticeable calm effect.

    I didn't think I had anxiety but now not so sure.

    Is it from serotonin production ?
    SpecialK82 likes this.
  2. ahmo

    ahmo Senior Member

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    Northcoast NSW, Australia
    I don't know the mechanism, but as I increased B12/folate I found a calm I'd always been pursuing, and eventually an end to life-long insomnia.:sleep:
    SpecialK82 likes this.
  3. PeterPositive

    PeterPositive Senior Member

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    Many people find that methyl-folate or methyl-B12 makes them more wired. Did you both had this problem too when starting the supplements or did you simply notice an improvement of the anxiety as you raised the dosage?

    So far I have had some problem with extra anxiety from those supplements but after some time they settled. I've not yet found a truly calming effect, which would be welcome, but they help with mental clarity and focus.

    When I feel "amped up" I usually take 250mg of GABA. That usually does the trick.

    Thanks
    SpecialK82 likes this.
  4. vortex

    vortex

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    Well it probably is serotonin then, because serotonin pathway converts into melatonin which puts you to sleep.
    How much methylfolate do you take.
  5. vortex

    vortex

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    Well if higher amounts of methylfolate can recycle bh4 and bh4 generates neuotransmitters I guess it could be a crapshoot or random effect if you get either calming neuros like serotonin or excitatory neuros like adrenaline. I guess it could go either way.
    Perhaps you could steer production by adding serotonin precursors like tryptophan or 5 htp.
  6. shah78

    shah78 Senior Member

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    Methylation took away a huge chunk of anxiety. I've never slept deeper(or atleast until I added pre/'probiotics). Of course it isn't surprising: I have almost the same snps as ahmo. The Yasko" clones" are on to something.
  7. LisaGoddard

    LisaGoddard Senior Member

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    Methylation also made me much calmer and sleep better. I tried reducing the treatment (due to the expense) and the symptoms of anxiety returned. So I upped them again, and it went.
    Certainly, works well for me.
  8. ahmo

    ahmo Senior Member

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    @PeterPositive I can't recall any increased anxiety as I continued on gradually increasing my dosages. And at some point it became evident I was now going to sleep promptly, and able to return to sleep easily if I awoke. Life-time firsts.

    Occasionally adding Mfolate gave me fairly immediate sense of restlessness, itchiness. When this happened I immediately took 1 mg B12, and the symptoms stopped just as quickly. I had this happen several times at bedtime, put the B12 in mouth and went to sleep. Amazing. This is the point at which Dr. Ben Lynch would advise niacin to slow things down, but I've been thrilled w/ the B12 solution. I worked up in 200mcg doses of folate, currently stabilized on 15mg Mfolate, 20mg MB12, 3.3mg AdB12.
    PeterPositive likes this.
  9. Critterina

    Critterina Senior Member

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    Are you a MTHFR A1298C mutant? If so, I'd say "yes" to the serotonin connection.

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