Hello, for the last year I've felt that my mental functioning has been slowing down and is not quite what it used to be. I'm only 25 and I notice that simple questions will take me longer to answer and I have quite a bit of mental strain. I know this is partly due to habits and negative self-talk. I am a totally different person, and I do not like myself at all. So please, any suggestions you have would be greatly apperciated. Any supplements, lifestyle changes, or anything in between.. I'm willing to do anything to return to who I was. However, I did a 23andme a ~7 months ago to hopefully get some insight as to what is going on. I found out I have quite a bit of mutations but upon research, it seemed to be nothing out of the ordinary. I did however notice that Nutrahacker,promethease,genetic genie, and livewello stated that, perhaps, methylated b vitamins may help (nutrahacker was the opposite 3/4 recommendations said to avoid methylated compounds). I started taking 5000mcg methylcobalamin, 800 mcg methylfolate. I was taking Jarrow's b-right and a methylated multi called BioVite. That seemed too much. I lowered the dose to just the Biovite (250mcg methylcobalamin and 400mcg of methylfolate). I do feel better after making the change, but it's only a tad better and I am experiencing worse symptoms from taking methylated vitamins. My question is, was nutrahacker correct? Should I avoid most methylated compounds and switch to adenosylcobalamin or Hydroxocobalamin and switch the methylfolate to folinic acid? I live a fairly healthy lifestyle. I do not eat processed foods, I don't eat gluten (I am currently testing for gluten sensitivity), gut health, nootropics, water consumption, I workout 5 days a week, watch my blood sugar, have no added sugar, herbal supplements... at this point I don't know what to do. I want to shake this fog i'm in.. for the last year I've have this unshakable depression, brain fog and overall low motivation. I was the polar opposite of this. Please, if it's within your power to help, do so; I will pay it forward..believe me. homozygous mutations: CYP2D6 S486T (GG) VDR Bsm (TT) MAO A R297R (T) CBS C699T (AA) heterozygous mutations: COMT V158M (AG) COMT H62H (CT) MTHFR C677T (AG) MTR A2756G (AG) MTRR A66G (AG) MTRR A664A (AG) BHMT-02 (CT) BHMT-08 (CT) AHCY-01 (CT) AHCY-19 (CT) CYP1A2 164A>C (AC) CYP1B1 L432V (CG) CYP1B1 N453S (CT) CYP1B1 R48G (CG) CYP2A6*2 1799T>A (AT) CYP2D6 100C>T (AG) CYP2D6 2850C>T (AG) CYP2C19*17 (CT) Thank you very much. I really appreciate any and every response.