Hello I haven't posted on here in a while, I just thought I'd pose a question to the more knowlegable members of the forum than myself, about methylation and Primary Sclerosing Cholangitis. I am under investigation for the disease PSC, a chronic liver disease caused by progressive inflammation and scarring of the bile ducts of the liver. I am at the moment taking Methyl-B12, NADH with Ribose, Active B-Complex (active B6), Magnesium, Selenium and Alpha Lipoic Acid. I haven't yet added in the Actifolate or Phosphatidyl. I am having quite good success with the protocol at the moment, I can now get out of bed and potter around the house for a good hour with rests in-between, type on the computer, read and shower by myself whereas before I was bedbound. I was off the protocol for a month when I was rushed into hospital and the difference off the meds was staggering, I was back to being bedbound and took me nearly two months to get right again (taking me to the present day as hospital was November). What I wanted to know is how does this protocol affect the liver if I have a disease of the bile ducts. I can't come off the protocol as I will go back to b'eing bedbound and I am very sick with liver pains and blocked bile ducts causing massive infections. I have raised levels of Glutathione in my blood as well which I don't want to get worse.